Preparation of Herbal Syrup for Liver
Balance in Accordance for Commercial Product
Arpan Debnath*, Baljinder Kaur, Shivani Singh, Biswajit Das
Department of Pharmacy, One
beat college of medical sciences, Bhira , U.P, 262901
*Correspondence: lavbis@gmail.com
DOI: https://doi.org/10.71431/IJRPAS.2025.4511
|
Article
Information
|
|
Abstract
|
|
Research Article
Received: 20/05/2025
Accepted: 27/05/2025
Published: 31/05/2025
Keywords
Herbal Syrup;
Liver; evaluation;
|
|
Most of herbal syrup was originally derived from plant herbal medicine
refers to use extract of fruit for medicinal purpose. Along with other dosage
from herbal drugs also formulated inform of syrups. Today syrup is used for treatment
of many ailments and to overcome symptoms of diseases. The antioxidant syrup
is used to treat the liver diseases. Formulation were prepared with variation
in quantity of ingredients and final volume of syrup. All prepared
formulation was by parameters like density, specific gravity, pH,
organoleptic characteristics. The results shown that herbal syrup formulation
number 4 is more stable and elegant as compared to other formulations.
|
INTRODUCTION
Herbal
liver syrup is a natural health supplement made from medicinal herbs
traditionally used to support and protect the liver. These syrups are commonly
formulated in Ayurvedic and Unani medicine systems and are designed to improve
liver function, aid digestion, and help the body eliminate toxins.[1,2] By
combining a variety of hepatoprotective (liver-protecting) herbs, such as
Babool Fali, Mulethi, Kutki, and Romi Mastogi, herbal liver syrups offer a
gentle yet effective way to manage common liver-related issues like fatty
liver, hepatitis, indigestion, and loss of appetite[.3,4]
Herbal
liver syrups are typically used as supportive therapy, and are especially
valued for being plant-based, non-toxic, and generally free from harsh side
effects when used correctly. They are available over-the-counter but should be
used responsibly, preferably under the guidance of a healthcare professional.[5,6]
METHODOLOGY
Herbal drugs are used in the
formulation of herbal syrup
Table 1. herbal drugs are used
in the formulation
|
S.no
|
Biological
source
|
|
1.
|
Hansraj
|
|
2.
|
Mulethi
|
|
3.
|
Kutki
|
|
4.
|
Babool fali
|
|
5.
|
Makoye
|
|
6.
|
Rumo mastogi
|
|
7.
|
Kasni beej
|
|
8.
|
Mussaber
|
Preparation
of fine powder from plants
All
plants part are firstly grind with grinder and also used with pestle and mortar
to prepare fine powder and sieve through sieve no 48,80,120 and stored in air
tight closed container. To prevent bacterial growth Powder material will pass
through under UV light.
Prepare
extract through Decoction
method
In this process, the crude drug
is boiled in a specified volume of water for a defined time; it is then cooled
and strained or filtered. This procedure is suitable for extracting
water-soluble, heat stable constituents. 100 gm olant part taken in 1000 ml
round bottom flask with 500 ml distilled water. And boiled them for upto 6 hr
in gentle heating 50degree. During boiling flask continuesly rotating for
circulation of heat. After 6 hr. material were filtered with filter paper and
collected filtrate were filter multiple time with masline cloth. They are
preserved by preservative 1% sodium benzoate. This solution were added in all
plant extract to prevent bacterial growth.
Formulation of Liver Syrup
To formulate liver syrup take
equal part of all powder approx 15gm each and mix them properly with the help
of double cone blender. For this material placed inside the blender and mix
them for 15 min at medium rotation. Collect all sample an again sieve them with
120 sieves number. The sieve and calculate uniform index. The plant powder was
mix and stored in air tight close container for 3-4 days.
|
Drugs
|
F1
|
F2
|
F3
|
F4
|
F5
|
|
Hansraj
|
2gm
|
1gm
|
1gm
|
3gm
|
3gm
|
|
Mulethi
|
1gm
|
1gm
|
1gm
|
1gm
|
2gm
|
|
Kutki
|
1 gm
|
1gm
|
1gm
|
1gm
|
2gm
|
|
Babool fali
|
1 gm
|
1gm
|
1gm
|
1gm
|
2gm
|
|
Makoye
|
1 gm
|
1gm
|
1gm
|
1gm
|
2gm
|
|
Rumo mastogi
|
1 gm
|
3gm
|
1gm
|
1gm
|
2gm
|
|
Kasni beej
|
1 gm
|
1gm
|
2gm
|
2gm
|
2gm
|
|
Mussaber
|
2 gm
|
1gm
|
2gm
|
2gm
|
2gm
|
|
Simple syrup
|
Up to 35ml
|
Up to 35ml
|
Up to 35ml
|
Up to 35ml
|
Up to 35ml
|
|
Preservatives
|
0.01%
|
0.01%
|
0.01%
|
0.01%
|
0.01%
|
|
Water
|
Up to 30ml
|
Up to 30ml
|
Up to 30ml
|
Up to 30ml
|
Up to 30ml
|
Evaluation parameter
Density
Clean the specific gravity
bottle thoroughly with chromic acid or nitric acid, then rinse it 2–3 times
with distilled water. If necessary, rinse with acetone and dry completely.
Weigh the empty dry bottle with its stopper (w1). Fill the bottle with the
unknown liquid, insert the stopper, and wipe off any excess. Weigh the filled
bottle (w2). Determine the weight of the liquid by subtracting w1 from w2: w3 =
w2 - w1.
Formula for density: Density of liquid under test
(syrup) = weight of liquid under test /volume of liquid under test = w3/v.
Specific gravity
Clean the specific gravity
bottle thoroughly using chromic or nitric acid, then rinse it two to three
times with purified water. If necessary, rinse with acetone and dry. Weigh the
empty dry bottle with stopper (w1). Fill the bottle with distilled water,
insert the stopper, wipe excess liquid, and weigh (w2). Replace water with the
test liquid after drying, repeat the procedure, and weigh again (w3). Use the
recorded weights to calculate the density of the liquid.
Formula for specific gravity: Specific gravity of liquid
under test (syrup) = weight of liquid under test /weight of water =
w5/w4.
Viscosity
Clean the Ostwald viscometer
thoroughly with warm chromic acid, and if needed, use acetone. Mount it
vertically on a stand. Fill the dry viscometer with water up to mark G. Measure
the time taken for water to flow from mark A to B, repeating thrice for
accuracy. Rinse the viscometer with the test liquid, fill up to mark A, and
record the time to reach mark B. Determine the densities of water and test
liquid as previously described.
Formula for viscosity
Viscosity = ×
Viscosity of water
pH determination
To prepare 30 mL of each
buffer, calculate the required volume of stock solutions. Mix appropriate
volumes of acid and conjugate base (or base and conjugate acid) to achieve the
desired pH. Allow the solutions to equilibrate for 15 minutes, then measure the
pH using a calibrated pH meter.
RESULTS
Evaluation parameter
|
Sr. No.
|
Parameter
|
F1
|
F2
|
F3
|
F4
|
F5
|
|
1.
|
Density
|
1.07gm.
|
1.06gm.
|
1.06gm.
|
1.06gm.
|
1.08
|
|
2.
|
Specific gravity
|
0.5357
|
0.5289
|
0.5189
|
0.5289
|
0.5369
|
|
3.
|
Viscosity
|
3.71cp.
|
3.62cp.
|
3.67cp.
|
3.67cp.
|
3.78cp.
|
|
4.
|
pH Determination
|
Neutral
|
Neutral
|
Neutral
|
Neutral
|
Neutral
|
|
5.
|
Organoleptic Characters
|
|
Color
|
Yellowish green
|
Yellowish green
|
Yellowish green
|
Yellowish green
|
Yellowish green
|
|
Odor
|
Aromatic
|
Alcoholic
|
Aromatic
|
Aromatic
|
Aromatic
|
|
Taste
|
Sweet
|
Sweet
|
Sweet
|
Sweet
|
Sweet
|
|
Appearance
|
Turbid
|
Turbid
|
Clear
|
Clear
|
Clear
|
A herbal syrup formulated with
Hansraj, Mulethi, Kutki, Babool fali, Makoye, Rumo mastogi, Kasni beej, and
Mussaber offers potent hepatoprotective benefits. Kutki and Makoye help
detoxify and regenerate liver cells, while Kasni beej enhances bile secretion.
Mulethi and Hansraj provide anti-inflammatory and antioxidant effects, aiding
liver function. Babool fali supports digestive health, and Mussaber soothes the
gastrointestinal tract. Rumo mastogi strengthens overall liver metabolism.
Together, these herbs promote liver health, manage hepatic disorders, and
support natural detoxification, making the syrup ideal for liver care.
CONCLUSION
The final formulation (F5)
demonstrated greater stability compared to formulations F1, F2, F3, and F4. It
was developed by minimizing the formulation errors identified in the earlier batches.
Formulation F5 exhibits significant antioxidant activity, indicating its
potential therapeutic benefits. Due to its enhanced stability and efficacy,
this formulation serves as a valuable reference for researchers and
pharmaceutical industries, enabling them to replicate and scale up similar
antioxidant-rich formulations for broader applications in health and wellness.
REFERENCES
1. Guroo I, Wani SA, Wani SM,
Ahmad M, and Masodi FA. A Review of production and processing of kiwifruit.
Journal of food processing and technology, 2017; 8(10): 2.
2. Banjari I, Misir A, Pavlić M,
Herath PN, Waisundara VY. Traditional Herbal Medicines for Diabetes Used in
Europe and Asia: Remedies From Croatia and Sri Lanka. Altern Ther Health Med.
2019 May;25(3):40-52.
3. Rahman MS, Islam R, Rana MM,
Spitzhorn LS, Rahman MS, Adjaye J, Asaduzzaman SM. Characterization of burn
wound healing gel prepared from human amniotic membrane and Aloe vera extract.
BMC Complement Altern Med. 2019 Jun 3;19(1):115.
4. Peng C, Zhang W, Dai C, Li W,
Shen X, Yuan Y, Yan L, Zhang W, Yao M. Study of the aqueous extract of Aloe
vera and its two active components on the Wnt/β-catenin and Notch signaling
pathways in colorectal cancer cells. J Ethnopharmacol. 2019 Jul
15:112092. doi: 10.1016/j.jep.2019.112092.
5. Gupta VK, Siddiqi NJ, Ojha AK, Sharma B. Hepatoprotective effect of Aloe
vera against cartap- and malathion-induced toxicity in Wistar rats. J
Cell Physiol. 2019 Aug;234(10):18329-18343. doi: 10.1002/jcp.28466. Epub
2019 Mar 19.