Abstract View

Author(s): Girisha Chaudhari1, Sofiya Morris2, Dr. Ashish Jain3

Email(s): 1girishachaudhari111@gmail.com

Address:

    Shri D. D. Vispute College of Pharmacy and Research Center, New Panvel- 410 206, Maharashtra, India

Published In:   Volume - 3,      Issue - 3,     Year - 2024

DOI: Not Available

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
To achieve high therapeutic activity and patient compliance, a unique kind of pharmaceutical delivery system is being created. Improvements in therapeutics activity have led to the development of various drug delivery strategies, still, some of these systems will have unsolved problems such as first-pass metabolism, poor drug stability in the GI tract and low absorption due to the interaction of food in case of IV. To overcome such a problem, in recent years transdermal drug delivery systems have gained popularity because they can meet every requirement that is needed and high quality. The approach towards TDDS is limited by the stratum corneum, the skin’s outermost layer which is 10-20 micrometers thick, which is considered as one of the inherent barrier for transdermal administration of medication. Among these transfersome are vesicular drug delivery techniques that have demonstrated the capacity to enhance the therapeutic margin, increase solubility, and stabilize and reduce the degradation of drug molecules. The ability of this carrier to squeeze itself and pass through narrow constriction and reach into deeper layers and systemic circulations. This review details the innovations that have been used to get around the drawbacks of TDDS, as well as advancements and present for better entrapment efficiency, Factors affecting the formation of transfersome, its characterization and marketed formulation available are highlighted.

Cite this article:
Girisha Chaudhari, Sofiya Morris. Dr. Ashish Jain. Nanoscale Navigation: A Review On Transfersomes for Transdermal Drug Delivery. IJRPAS, May-June 2024; 3(3): 64-79.


1.      Chaurasiya P, Ganju E, Upmanyu N, Ray SK, Jain P. Transfersomes: a novel technique for transdermal drug delivery. J Drug Deliv Ther [Internet]. 2019; 9(1):279–85. Available from: http://dx.doi.org/10.22270/jddt.v9i1.2198

2.      Kumar R, Philip A. Modified transdermal technologies: Breaking the barriers of drug permeation via the skin. Trop J Pharm Res [Internet]. 2007; 6(1). Available from: http://dx.doi.org/10.4314/tjpr.v6i1.14641

3.      Rajkumar J, Sree Lakshmi RK, Vineesha S. A new approach to transdermal drug delivery using transfersomes-based nanoencapsulation: A research update. Asian J Pharm Res Dev [Internet]. 2022; 10(1):64–70. Available from: http://dx.doi.org/10.22270/ajprd.v10i1.1082

4.      Modi CD, Bharadia PD. Transfersomes: A new dominant for transdermal drug delivery. Am J PharmTech Res. 2012; 2:71–91

5.      Benson HAE. Transfersomes for transdermal drug delivery. Expert Opin Drug Deliv [Internet]. 2006; 3(6):727–37. Available from: http://dx.doi.org/10.1517/17425247.3.6.727

6.      Kumar PK, Kumar RS. Review on Transferosomes and Transferosomal Gels. J Pharm Res Int [Internet]. 2021; 114–26. Available from: http://dx.doi.org/10.9734/jpri/2021/v33i43b32532

7.      Solanki D, Kushwah L, Motiwale M, Chouhan V. Transferosomes-a review. World Journal of Pharmacy and Pharmaceutical Sciences. 2016; 5:435–49

8.      Reddy S. Transferosomes-Novel Drug Delivery System -A Review. International Journal of Creative Research Thoughts. 2020(9):2320–882.

9.      Sachan R, Parashar T, Singh V, Singh G, Tyagi S, Patel C, et al. DRUG CARRIER TRANSFERSOMES: A NOVEL TOOL for TRANSDERMAL DRUG DELIVERY SYSTEM. International Journal of Research and Development in Pharmacy & Life Sciences. 2013(2):309–16.

10.  Piumitali B, Neeraj U, Jyotivardhan J. Transfersomes — A nanoscience in transdermal drug delivery and its clinical advancements. Int J Nanosci [Internet]. 2020;19(04):1950033. Available from: http://dx.doi.org/10.1142/s0219581x19500339

11.  Wahi N, Kaur G, Narang JK. Transferosomes - A lipid based vesicular carrier with versatile applications. Int J Pharm Sci Rev Res [Internet]. 2023;81(1). Available from: http://dx.doi.org/10.47583/ijpsrr.2023.v81i01.030

12.  Fatima A, Suresh Babu M. Transferosomes: A Novel Approach for Nanoencapsulation of Drugs for Transdermal Delivery. 2023:27–37.

13.  Garg V, Singh H, Bimbrawh S, Singh SK, Gulati M, Vaidya Y, et al. Ethosomes and transfersomes: Principles, perspectives and practices. Curr Drug Deliv [Internet]. 2017;14(5). Available from: http://dx.doi.org/10.2174/1567201813666160520114436

14.  Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill F, et al. Surfactant effects on lipid-based vesicles properties. J Pharm Sci [Internet]. 2018;107(5):1237–46. Available from: http://dx.doi.org/10.1016/j.xphs.2018.01.005

15.  Opatha SAT, Titapiwatanakun V, Chutoprapat R. Transfersomes: A promising nanoencapsulation technique for transdermal drug delivery. Pharmaceutics [Internet]. 2020;12(9):855. Available from: http://dx.doi.org/10.3390/pharmaceutics12090855

16.  El Zaafarany GM, Awad GAS, Holayel SM, Mortada ND. Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery. Int J Pharm [Internet]. 2010;397(1–2):164–72. Available from: http://dx.doi.org/10.1016/j.ijpharm.2010.06.034

17.  Gupta A. Transfersomes: A novel vesicular carrier for enhanced transdermal delivery of sertraline: Development, characterization, and performance evaluation. Sci Pharm [Internet]. 2012;80(4):1061–80. Available from: http://dx.doi.org/10.3797/scipharm.1208-02

18.  Sheo DM, Shweta A, Ram CD, Ghanshyam M, Girish K, Sunil KP. Transfersomes-A novel vesicular carrier for enhanced transdermal delivery of stavudine: Development, characterization and performance evaluation. J Scientific Speculations and Res. 2010;1(1):30–6.

19.  Patel R, Singh SK, Singh S, Sheth NR, Gendle R. Development and Characterization of Curcumin Loaded Transfersomes for Transdermal Delivery. J Pharm Sci Res. 2009;1(4):71–80.

20.  Jain S, Jain P, Umamaheshwari RB, Jain NK. Transfersomes—A novel vesicular carrier for enhanced transdermal delivery: Development, characterization, and performance evaluation. Drug Dev Ind Pharm [Internet]. 2003;29(9):1013–26. Available from: http://dx.doi.org/10.1081/ddc-120025458

21.  Walve JR, Bakliwal SR, Rane BR, Pawar SP. Transfersomes: A surrogated carrier for transdermal drug delivery system”. International Journal of Applied Biology and Pharmaceutical Technology. 2011;2(1):201–14

22.  Wang J, Zhao Y, Zhai B, Cheng J, Sun J, Zhang X, et al. Phloretin transfersomes for transdermal delivery: Design, optimization, and in vivo evaluation. Molecules [Internet]. 2023;28(19):6790. Available from: http://dx.doi.org/10.3390/molecules28196790

23.  Jain SK, Gupta Y, Jain A, Rai K. Enhanced transdermal delivery of acyclovir sodium via elastic liposomes. Drug Deliv [Internet]. 2008;15(3):141–7. Available from: http://dx.doi.org/10.1080/10717540801952407

24.  Ätzlein S, Cevc. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: a high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes): STRATUM CORNEUM STRUCTURE BY CONFOCAL MICROSCOPY. Br J Dermatol [Internet]. 1998;138(4):583–92. Available from: http://dx.doi.org/10.1046/j.1365-2133.1998.02166.x

25.  Wu P-S, Li Y-S, Kuo Y-C, Tsai S-J, Lin C-C. Preparation and evaluation of novel transfersomes combined with the natural antioxidant resveratrol. Molecules [Internet]. 2019;24(3):600. Available from: http://dx.doi.org/10.3390/molecules24030600

26.  Cevc G, Gebauer D, Stieber J, Schätzlein A, Blume G. Ultraflexible vesicles, Transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biochim Biophys Acta Biomembr [Internet]. 1998;1368(2):201–15. Available from: http://dx.doi.org/10.1016/s0005-2736(97)00177-6

27.  Jain A, Jain A, Gulbake A, Shilpi S, Hurkat P, Jain SK. Peptide and protein delivery using new drug delivery systems. Crit Rev Ther Drug Carrier Syst [Internet]. 2013;30(4):293–329. Available from: http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.2013006955

28.  Chaulagain B, Jain A, Tiwari A, Verma A, Jain SK. Passive delivery of protein drugs through transdermal route. Artif Cells Nanomed Biotechnol [Internet]. 2018;46(sup1):472–87. Available from: http://dx.doi.org/10.1080/21691401.2018.1430695

29.  Cevc G. Isothermal lipid phase”. Transitions Chemistry and Physics of Lipids. 1991;57:293–9.

30.  Hafer C, Goble R, Deering P, Lehmer A, Breut J. Formulation of interleukin-2 and interferon-alpha containing ultra-deformable carriers for potential transdermal application”. Anticancer Res. 1999;19(2c):1505–7.

31.  Ghanbarzadeh S, Arami S. Enhanced transdermal delivery of Diclofenac sodium via conventional liposomes, ethosomes, and transfersomes. Biomed Res Int [Internet]. 2013;2013:1–7. Available from: http://dx.doi.org/10.1155/2013/616810

32.  Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill F, et al. Formulation and optimisation of novel transfersomes for sustained release of local anaesthetic. J Pharm Pharmacol [Internet]. 2019;71(10):1508–19. Available from: http://dx.doi.org/10.1111/jphp.13149

33.  Potisuwan S, Apichatwatana N, Rujivipat S. Improved skin permeation of transferosomes containing Eulophia macrobulbon extract. Colloids Surf B Biointerfaces [Internet]. 2023;229(113474):113474. Available from: http://dx.doi.org/10.1016/j.colsurfb.2023.113474

34.  Chen M, Shamim MA, Shahid A, Yeung S, Andresen BT, Wang J, et al. Topical delivery of carvedilol loaded nano-transfersomes for skin cancer chemoprevention. Pharmaceutics [Internet]. 2020;12(12):1151. Available from: http://dx.doi.org/10.3390/pharmaceutics12121151

35.  Raut SS, Rane BR, Jain AS. Development and evaluation of ebastine-loaded transfersomal nanogel for the treatment of urticaria (autoimmune disease). In: ASEC 2023. Basel Switzerland: MDPI; 2023.

36.  Schlich M, Lai F, Murgia S, Valenti D, Fadda AM, Sinico C. Needle-free jet injection of intact phospholipid vesicles across the skin: a feasibility study. Biomed Microdevices [Internet]. 2016;18(4). Available from: http://dx.doi.org/10.1007/s10544-016-0098-3

37.  Sardana V, Burzynski J, Zalzal P. Safety and efficacy of topical ketoprofen in transfersome gel in knee osteoarthritis: A systematic review: . Musculoskeletal Care [Internet]. 2017;15(2):114–21. Available from: http://dx.doi.org/10.1002/msc.1163

38.  Garg V, Singh H, Bhatia A, Raza K, Singh SK, Singh B, et al. Systematic development of transethosomal gel system of piroxicam: Formulation optimization, in vitro evaluation, and ex vivo assessment. AAPS PharmSciTech [Internet]. 2017;18(1):58–71. Available from: http://dx.doi.org/10.1208/s12249-016-0489-z

39.  Balata GF, Faisal MM, Elghamry HA, Sabry SA. Preparation and characterization of ivabradine HCl transfersomes for enhanced transdermal delivery. J Drug Deliv Sci Technol [Internet]. 2020;60(101921):101921. Available from: http://dx.doi.org/10.1016/j.jddst.2020.101921

40.  Yang Y, Ou R, Guan S, Ye X, Hu B, Zhang Y, et al. A novel drug delivery gel of terbinafine hydrochloride with high penetration for external use. Drug Deliv [Internet]. 2015;22(8):1086–93. Available from: http://dx.doi.org/10.3109/10717544.2013.878856

41.  Malakar J, Sen SO, Nayak AK, Sen KK. Formulation, optimization and evaluation of transferosomal gel for transdermal insulin delivery. Saudi Pharm J [Internet]. 2012;20(4):355–63. Available from: http://dx.doi.org/10.1016/j.jsps.2012.02.001

 

 

 

 

Related Images:



Recent Images



A Review on Diabetes Mellitus: Type1 & Type2
Formulation and Evaluation of Herbal Hair Mask
FT-IR and UV-Vis Spectroscopic studies of Cd(II), Hg(II) and Zn(II)  metal complexes of 2-methoxy-2
FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2
Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System
A Review on Antiseptic Gargle
Formulation and Characterisation of Papaya Leaf Gel
Formulation and Characterisation of Herbal Neem Soap
Formulation and Evaluation of Herbal Hair Serum
Pharmaceutical Marketing Role to Adapt Drug Promotional Practices at the duration times  of Pandemic Covid-19

Tags


Recomonded Articles:

Author(s): Bhagyashri C. Patel; Sandhya R. Chavhan; H.P. Suryawanshi; R. A. Ahirrao

DOI:         Access: Open Access Read More

Author(s): Pravin V. Gomase; R. R. Patil; Sunil P. Pawar

DOI: NA         Access: Open Access Read More

Author(s): Shaikh Aminoddin Raisoddin; Shifa Maniya; Sayeeda Begum; Naziya Shaikh.

DOI:         Access: Open Access Read More

Author(s): Hasanen Pinjari; Rehan Deshmukh; Khan Faizan; Dr. Gulam Javed.

DOI:         Access: Open Access Read More

Author(s): Kamil Hafiz Anees Ahmed Quazi; Dr. Majaz Quazi; Wasil Jalees Quazi; Dr. G. J. Khan.

DOI:         Access: Open Access Read More

Author(s): Harshadeep Seal; Namrata Koushik

DOI:         Access: Open Access Read More

Author(s): Shah Kaunen; Pathan Ahemad; Shah Sahil; Khatik Ali; Abdul Kashif; Abu Asim Azmi

DOI:         Access: Open Access Read More

Author(s): Devadatta Pandurang Hatim; Sachinkumar V. Patil; Sachin Mali

DOI:         Access: Open Access Read More

Author(s): Venkatesh; Chaithra N; Parthasarathi K Kulkarni; Siddartha H N; Hanumanthachar Joshi K

DOI:         Access: Open Access Read More

Author(s): Girisha Chaudhari;Sofiya Morris; Dr. Ashish Jain

DOI:         Access: Open Access Read More

Author(s): Mehul P. Bagde; Mukesh Rajpurohit; Lalit Chaudhary

DOI:         Access: Closed Access Read More

Author(s): Sarang Chavan; Dr. Gulam Javed Khan

DOI:         Access: Open Access Read More

Author(s): Apurva Arabhavi; Manisha Mane; Neha Desap Sachin Mali; Akanksha Sawant.

DOI:         Access: Open Access Read More

Author(s): Mansoori Safwan Salim; Prof. Rehan Deshmuhk; Dr. G.J. Khan; Shaikh Amaan; Sayyed Ahamad Sayyed Kaleem; Hamza Iliyas Amliwala

DOI:         Access: Open Access Read More

Author(s): Mohammad Zaid*; Prof. Imran Kalam; Dr. Quazi Majaz

DOI:         Access: Open Access Read More

Author(s): Mahesh Dilip Mane; Nilesh Shashikant Patole; Vetal Nana Kodalkar; Sanket Arun Metkari.

DOI:         Access: Open Access Read More

Author(s): Quazi Kamil Hafiz Anees Ahemad; Dr. Majaz Quazi; Quazi Wasil; Dr. G. J. Khan

DOI:         Access: Open Access Read More

Author(s): Lilachand B. Patil; Khushal K. Chaudhari; Eknath Jagannath Patil

DOI:         Access: Open Access Read More

Author(s): Soni Rishita1*, Salunke Khushi1, Patel Harsh1, Patel Aastha1, Taufik Mulla2, Ambika Nand Jha3

DOI:         Access: Open Access Read More