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International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544 | Issues per year: Bi-monthly | Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System

Author(s): Magendran Rajendiran1*¹, Muruganand R2², Abhisek Kumar Sinha2³, Mohamed Raashith M S2⁴, Jasitha Begam M2⁵, Usharani G2⁶, Dhivyari D2⁷, Deepika T2⁸

Email(s): ¹magendran1988@gmail.com

Address:

1. School of Pharmaceutical Sciences, Vels University India 2. Sir Issac Newton College of Pharmacy, The Tamil Nadu Dr. M.G.R. Medical University

Published In: Volume - 4, Issue - 4, Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4413

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ABSTRACT:
This study presents a UV-Visible spectrophotometric analysis of paracetamol and ibuprofen using a mixed solvent system of ethanol and sodium hydroxide (NaOH) in a 3:1 ratio. The objective was to evaluate the spectral behavior and compatibility of these drugs within this solvent environment, with a focus on their solubility, absorbance maxima, and potential spectral interference. Paracetamol and ibuprofen exhibited distinct absorbance peaks at 243 nm and 221 nm, respectively. The presence of NaOH did not significantly alter the peak positions or intensities, indicating minimal interference and good chemical stability in the selected solvent mixture. Calibration curves for both drugs showed linearity within the tested concentration ranges, adhering to Beer-Lambert’s law. These findings demonstrate that the ethanol–NaOH mixture provides a suitable medium for the accurate and simultaneous UV spectrophotometric analysis of paracetamol and ibuprofen, supporting its potential use in routine pharmaceutical quality control.

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Cite this article:
Magendran Rajendiran, Muruganand R, Abhisek Kumar Sinha, Mohamed Raashith M S, Jasitha Begam M, Usharani G, Dhivyari D, Deepika T.Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System. IJRPAS, April 2025; 4 (4): 124-134.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4413

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