Author(s):
Mudigonda Sowjanya*1, Nishad2, Fariya3, Malla Rajeshwari4, Dr. K. Lakshmi Surekha5
Email(s):
1mudigonda.sowjanya2@gmail.com
Address:
Department of pharmacy practice, Marri Laxman Reddy institute of Pharmacy, Dundigal, Hyderabad, Telangana, 500043
Published In:
Volume - 4,
Issue - 2,
Year - 2025
DOI:
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ABSTRACT:
Introduction: Iron deficiency anaemia is the most common type of anaemia in pregnant women. Due to extra demands during pregnancy, they are more susceptible to anaemia. The demand of iron is generally low in the first trimester and high in the third trimester. In India 90% of anaemia’s are caused due to iron deficiency. Aim and Objectives: To compare the safety and efficacy of ferrous ascorbate and ferrous fumarate in the treatment of iron deficiency anaemia in pregnant women and to and to assess its cost effectiveness ratio. Materials and Methodology: About 118 subjects were included in the study based on the study criteria. They were divided randomly into two groups with 59 subjects each. Group A received ferrous ascorbate 100mg twice daily and Group B received ferrous fumarate 100mg twice daily for 60 days. Microsoft Excel was used to perform paired t-test and to calculate mean, standard deviation, confidence interval and p-value.
Results: There was a significant rise in the mean Hb level from 9.74 ± 0.91 and 10.43 ± 0.38 to 11.49 ± 0.84 and 11.36 ± 1.15 in groups A and B respectively (p= <0.001). 11 subjects from group A and 7 subjects from group B showed minor gastrointestinal side effects.
Conclusion: Individuals administered with ferrous ascorbate exhibited a significant increase in crucial blood parameters. But ferrous fumarate showed slightly low side effects and cost effectiveness ratio compared to that of ferrous ascorbate.
Cite this article:
Mudigonda Sowjanya, Nishad, Fariya, Malla Rajeshwari, Dr. K. Lakshmi Surekha. A Comparative Study of Ferrous Ascorbate and Ferrous Fumarate in Treating Iron Deficiency Anaemia during Pregnancy: Efficacy and Safety analysis. IJRPAS, Feb 2025; 4 (2): 1-12.
1.
Bansal
R, Bedi M,
Kaur J, Kaur
K, Shergill HK,
Khaira HK, Suri
V. Prevalence and
factors associated with
anemia among pregnant
women attending antenatal
clinic. Adesh University
Journal of Medical
Sciences & Research.
2020 Jul 23;2(1):42-8.
DOI:10.25259/AUJMSR_8_2020.
2.
Sabina
S, Iftequar S,
Zaheer Z, Khan
MM, Khan S.
An overview of
anemia in pregnancy.
J Innov Pharm
Biol Sci. 2015;2(2):144-51.
3.
Faiza
AN, Saadia AG.
Types, Experience and
Associated Factors of
Anemia among Pregnant
Women-2018. Age. 2019;20:20-40.
4.
Garzon
S, Cacciato PM,
Certelli C, Salvaggio
C, Magliarditi M,
Rizzo G. Iron
deficiency anemia in
pregnancy: Novel approaches
for an old
problem. Oman medical
journal. 2020 Sep;35(5):e166. DOI: 10.5001/omj.2020.108. PMCID:
PMC7477519; PMID: 32953141.
5.
Georgieff
MK. Iron deficiency
in pregnancy. American
journal of obstetrics
and gynecology. 2020
Oct 1;223(4):516-24. DOI: 10.1016/j.ajog.2020.03.006.
6.
Piskin
E, Cianciosi D,
Gulec S, Tomas
M, Capanoglu E.
Iron absorption: factors,
limitations, and improvement
methods. ACS omega.
2022 Jun 10;7(24):20441-56.
7.
Abu-Ouf
NM, Jan MM.
The impact of
maternal iron deficiency
and iron deficiency
anemia on child’s
health. Saudi medical
journal. 2015;36(2):146. DOI: 10.15537/smj.2015.2.10289. PMCID:
PMC4375689; PMID: 25719576.
8.
Murugesan
S, Sudakshina K,
Adhimoolam M, Arthi
S. Comparative study
on efficacy, tolerability,
and cost of
different iron supplements
among antenatal women with iron-deficiency anemia.
National Journal of
Physiology, Pharmacy and
Pharmacology. 2023 Mar
31;13(4):802-. DOI: 10.5455/njppp.2023.13.09427202218092022.
9.
Palihawadana TS,
Goonewardene IM, Motha
MB, Williams HS.
Iron deficiency anaemia
in pregnancy: diagnosis,
prevention and treatment.
Sri Lanka Journal
of Obstetrics and
Gynaecology. 2014 Dec
1;36(3):61-5. DOI: 10.4038/sljog.v36i3.7713.
10.
Govindappagari S,
Burwick RM. Treatment
of iron deficiency
anemia in pregnancy
with intravenous versus
oral iron: systematic
review and meta-analysis. American
journal of perinatology.
2019 Mar;36(04):366-76. DOI:
10.1055/s-0038-1668555.
11.
Eesha
A, Yogita K,
Manju T, Girija
W, Vijaya P.
Pharmacoeconomic evaluation of
ferrous ascorbate, ferrous
fumarate and iron
polymaltose complex in
14 to 24
weeks of gestation.
Inte J Health
Sci Res. 2015;5(11):339-44.