ABSTRACT:
Pluronic–lecithin organogels (PLOs) have emerged as promising carriers for dermal and transdermal drug delivery due to their unique ability to incorporate both hydrophilic and lipophilic drugs within a single system. This review provides an overview of the structure and function of the skin, along with key factors influencing drug penetration, particularly the barrier role of the stratum corneum. The limitations of conventional topical dosage forms and the need for advanced delivery systems such as organogels are also highlighted. Organogels are discussed in detail with respect to their composition, mechanism of formation, and classification, with a specific focus on pluronic–lecithin systems. These systems combine a lipophilic lecithin phase with a hydrophilic pluronic phase, resulting in improved drug solubilization, enhanced permeation, and better stability. Various formulation strategies and preparation methods are summarized to provide insight into their development and optimization. The review further outlines important evaluation parameters used to assess organogel performance, including organoleptic characteristics, pH, viscosity, spreadability, in vitro drug release, and gel–sol transition temperature. These parameters play a crucial role in determining the quality, stability, and therapeutic efficacy of the formulation. In addition, the advantages of organogels, such as controlled drug release, improved patient compliance, and reduced systemic side effects, are discussed alongside their limitations and challenges. In conclusion, pluronic–lecithin organogels represent a versatile and efficient platform for topical drug delivery. Future research focusing on the integration of nanotechnology and novel permeation enhancers may further enhance their clinical applicability and therapeutic effectiveness.