Therapeutic Peptides in Action: A Comprehensive Review of Delivery Technologies and Biomedical Applications along with Future Perspectives

Dr. M. Sunitha Reddy; Dr. K. Anie Vijetha; Vaishnavi Bakka*

editorijrpas@gmail.com

International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544 | Issues per year: Monthly | Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Therapeutic Peptides in Action: A Comprehensive Review of Delivery Technologies and Biomedical Applications along with Future Perspectives

Author(s): Dr. M. Sunitha Reddy¹, Dr. K. Anie Vijetha², Vaishnavi Bakka*³

Email(s): ¹vaishnavireddybakka1@gmail.com

Address:

Department of Pharmaceutics, Centre for Pharmaceutical sciences, University college of engineering, science and technology JNTUH, Kukatpally, Hyderabad, 500085

Published In: Volume - 4, Issue - 9, Year - 2025

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ABSTRACT:
Peptides are short chains of amino acids they possess unique properties such as their diversity in structure, tunable Hydrophobicity/Hydrophilicity and their inherent Bio compatibility. Peptide-based drug delivery systems (PBDDS) have emerged as versatile systems bridging small molecules and biologics. Over the last decade, innovations in peptide chemistry, self-assembly, conjugation strategies, and targeting strategies have transformed peptides from passive excipients used into active delivery vehicles. This review focuses on peptide drug conjugates (PDCs), cell-penetrating peptides (CPPs), self-assembled nanostructures, hybrid nanoparticles and hydrogels. Also gives an insight on transitional challenges including stability and immunogenicity, including Opportunities in AI-guided peptide design, oral/transmucosal delivery.

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