International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Solubility Enhancement of Poorly Soluble Drugs

Author(s): Manali Maheshwar Patil.*1, Momin Abrarul Haque2, Bhakti Narayan Patil3, Mayur Suresh Reddy4, Ankita Bhagoji Dupare.5

Email(s): 1manalipatil05312@gmail.com

Address:

    M. S. College of Pharmacy, Gaurapur-Kudus Rd, Dist. Palghar, Maharashtra, India.

Published In:   Volume - 2,      Issue - 5,     Year - 2023

DOI: Not Available

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ABSTRACT:
The solubility behavior of drugs remains one of the most challenging parts of formulation development. High solubility and permeability are found in only 8% of the novel compound. The drug's therapeutic effectiveness depends upon bioavailability and ultimately upon solubility. Salt formation, particle size reduction, etc. have commonly been used to increase the dissolution rate of drugs, there are some practical restrictions with these techniques the desired bioavailability enhancement may not always be achieved. Solid dispersion seems to be an applicable technique for overcoming this problem. In this review, it is intended to discuss recent advances related to the area of solid dispersion. Finally, industrially achievable alternative approaches in the manufacture of solid dispersion have been highlighted.

Keywords:

Cite this article:
Manali Maheshwar Patil.*, Momin Abrarul Haque, Bhakti Narayan Patil, Mayur Suresh Reddy, Ankita Bhagoji Dupare. Solubility Enhancement of Poorly Soluble Drugs. IJRPAS, Sep-Oct 2023; 2(5): 56-70.


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