ABSTRACT:
The pharmacokinetics and efficacy of different medications are influenced by cytochrome P450 enzymes, which are essential for drug metabolism. This abstract delves into the complex roles that P450 plays in catalyzing phase I reactions, including reduction, hydrolysis, and oxidation. P450 isoform genetic polymorphisms and substrate specificity are factors that influence inter-individual differences in drug response, metabolism, and side effects. Comprehending the complex interactions between pharmaceuticals and P450 is crucial for customized medicine, as it allows for medication schedules that maximize therapeutic effects while reducing adverse effects. This review explores the potential applications of P450 knowledge for improved drug development and patient care, as well as the molecular mechanisms and clinical implications.
Cite this article:
Musab Khan, Saad Ahmad Khan, Pathan Faizan Khan, Mochi Muzammil, Mohammad Saqib UsmaniThe Role of Cytochrom P450 in Drug Metabolism. IJRPAS, 2024; 3(1): 117-122.
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