editorijrpas@gmail.com

International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544 | Issues per year: Bi-monthly | Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

Abstract View

Advancements in Liquisolid Compacts Technology Formulation and Characterization

Author(s): Mohammad Faizan¹, Ismail Moazzam.²

Email(s): ¹md.faizan189070@gmail.com

Address:

Department of Pharmaceutics, Maulana Azad Educational Trust’s Y.B. Chavan College of Pharmacy, Aurangabad 431003, Maharashtra

Published In: Volume - 3, Issue - 3, Year - 2024

DOI: Not Available

View HTML

View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
The liquisolid approach shows promise in addressing bioavailability and solubility issues in medications. The use of organic solvents that are soluble in water, such as glycerine, propylene glycol, or polyethylene glycols, improves wettability and guarantees the molecular dispersion of medications that are insoluble in water. Aerosil-200 is a coating substance and microcrystalline cellulose is a common carrier. Liquisolid compacts have more surface area, better wettability, water solubility, and improved drug release. Using this method, medication suspensions or solutions are turned into dry, pliable, and compressible powders. Evaluations of flow behaviour, wettability, hydrophilicity, solubility, drug content, and analytical methods such as XRD, FT-IR, and DSC are all included in the characterization process. Liquisolid systems present a new and effective option to formulate pharmaceuticals that are both water-soluble and water-insoluble, opening up a route for better medication performance, sustained drug delivery, and greater solubility.

Keywords:

Cite this article:
Mohammad Faizan, Ismail Moazzam.Advancements in Liquisolid Compacts Technology Formulation and Characterization. IJRPAS, May-June 2024; 3(3): 220-237.

REFERENCES:

1. Manogar PG, Hari BV, Devi DR. Emerging liquisolid compact technology for solubility enhancement of BCS class-II drug. Journal of Pharmaceutical Sciences and Research. 2011 Dec 1;3(12):1604.

2. Lu M, Xing H, Jiang J, Chen X, Yang T, Wang D, Ding P. Liquisolid technique and its applications in pharmaceutics. Asian journal of pharmaceutical sciences. 2017 Mar 1;12(2):115-23.

3. Spiraeas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. International Journal of Pharmaceutics. 1998 May 18;166(2):177-88.

4. Jamkhandi VG. Formulation and evaluation of immediate release tablet of carvedilol using liquisolid compacts technique for solubility enhancement. Asian Journal of Pharmaceutics (AJP). 2016 Sep 10;10(03).

5. Lohithasu D, Ramana JV, Girish P, Harsha IN, Madhu G, Lavanya K, Sri DS. A latest review on liquisolid technique as a novel Approach. World Journal of Pharmaceutical Research. 2014 Apr 15;3(4):479-93.

6. Hentzschel CM, Sakmann A, Leopold CS. Suitability of various excipients as carrier and coating materials for liquisolid compacts. Drug development and industrial pharmacy. 2011 Oct 1;37(10):1200.

7. Vraníková B, Svačinová P, Marushka J, Brokešová J, Holas O, Tebbens JD, Šklubalová Z. The importance of the coating material type and amount in the preparation of liquisolid systems based on magnesium aluminometasilicate carrier. European Journal of Pharmaceutical Sciences. 2021 Oct 1;165:105952.

8. Javad Zadeh Y, Siahi-Shadbad MR, Barzegar-Jalali M, Nokhodchi A. Enhancement of dissolution rate of piroxicam using liquisolid compacts. Il Farmaco. 2005 Apr 1;60(4):361-5.

9. Jadhav NR, Irny PV, Patil US. Solid state behaviour of progesterone and its release from Neusilin US2 based liquisolid compacts. Journal of Drug Delivery Science and Technology. 2017 Apr 1; 38:97-106.

10. Bhattacharyya S, Ramachandran D. Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous silica as a novel adsorbent. Materials Letters: X. 2022 Dec 1;16:100171.

11. Vraníková B, Pavloková S, Gajdziok J. Experimental design for determination of effects of super disintegrant combinations on liquisolid system properties. Journal of pharmaceutical sciences. 2017 Mar 1;106(3):817-25.

12. Sabri LA, Hussien AA. Formulation and In-Vitro Characterization of Solidified Nebivolol Self-Nano emulsion using Liquisolid Technique. Systematic Reviews in Pharmacy. 2020 Mar 1;11(3).

13. Khames A. Investigation of the effect of solubility increase at the main absorption site on bioavailability of BCS class II drug (risperidone) using liquisolid technique. Drug delivery. 2017 Jan 1;24(1):328-38.

14. Singh SK, Srinivasan KK, Gowtham Rajan K, Prakash D, Gaikwad NB, Singare DS. Influence of formulation parameters on dissolution rate enhancement of glyburide using liquisolid technique. Drug development and industrial pharmacy. 2012 Aug 1;38(8):961-70

15. Thakur N, Khokra SL, Sharma D, Thakur NS, Purohit R, Arya V. A review on pharmaceutical application of liquisolid technique. Am. J. Pharmtech. Res. 2011; 1:1-8.

16. Yadav VB, Yadav AV. Liquisolid granulation technique for tablet manufacturing: an overview. Journal of Pharmacy Research. 2009 Apr;2(4):670-4.

17. Pawar JD, Jagtap RS, Doijad RC, Pol SV, Desai JR, Jadhav VV, Jagtap SR. Liquisolid compacts: a promising approach for solubility enhancement. Journal of Drug Delivery and Therapeutics. 2017 Jul 15;7(4):6-11.

18. Deshmukh AS, Mahale VG, Mahajan VR. Liquisolid compact techniques: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014;6(3):161-6.

19. Pathak A, Goyal R, Agrawal P, Rajput S, Tiwari G, Shivhare R. A review on liquisolid technology. World J Pharma Res. 2012 Jun 12;1(3):500-12.

20. Kumar Nagabandi V, Ramarao T, Jayaveera KN. Liquisolid compacts: a novel approach to enhance bioavailability of poorly soluble drugs. Int J Pharm Res Allied Sci. 2011;1(3):89-102.

21. Varshosaz, J., Ghassami, E., &Ahmadipour, S. (2018). Crystal engineering for enhanced solubility and bioavailability of poorly soluble drugs. Current Pharmaceutical Design, 24(21), 2473-2496.

22. Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Advanced drug delivery reviews. 1997 Jan 15;23(1-3):3-25.

23. Gorle AP, Chopade SS. Liquisolid technology: preparation, characterization and applications. Journal of Drug Delivery and Therapeutics. 2020 Jun 15;10(3-s):295-307.

24. Vogt, M.; Kunath, K.; Dressman, J.B. Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: Comparison with commercial preparations. Eur. J. Pharm. Biopharm. 2008, 68, 283–288

25. Patel US, Patel KC. Liquisolid technique for poorly soluble drugs. Journal of Scientific and Industrial Research. 2013;2(1):145-59.

26. Tiong N, Elkordy AA. Effects of liquisolid formulations on dissolution of naproxen. European Journal of Pharmaceutics and Biopharmaceutics. 2009 Nov 1;73(3):373-84.

27. Kamalakkannan, V.; Puratchikody, A.; Masilamani, K.; Senthilnathan, B. Solubility enhancement of poorly soluble drugs by solid dispersion technique—A review. J. Pharm. Res. 2010, 3, 2314–2321.

28. Spireas S, Sadu S. Enhancement of prednisolone dissolution properties using liquisolid compacts. International Journal of Pharmaceutics. 1998 May 18;166(2):177-88.

29. Nokhodchi A, Hentzschel CM, Leopold CS. Drug release from liquisolid systems: speed it up, slow it down. Expert opinion on drug delivery. 2011 Feb 1;8(2):191-205.

30. Patel UB, Modi DC, Shah DP. Liquisolid compacts: A review. International Journal of Advances in Pharmaceutical. 2017;6(7):110-3.

31. Bandari S, Mittapalli RK, Gannu R, Rao YM. Oro dispersible tablets: An overview. Asian journal of pharmaceutics, Jan 2008, 2-11.

32. Reddy et al. Formulation and evaluation of candesartan Immediate release tablets by

using liquisolid Technique.WJPPS,2014,3(2): 2270-2282.

33. Shailesh T. Prajapati, Hitesh H. Bulchandani,DashrathM. Patel, Suresh K. Dumaniya, and

Chhaganbhai N. Patel. Formulation and Evaluation of Liquisolid Compacts for Olmesartan Medoxomil. Journal of Pharmaceutics.2013,1-9.

34. Kamagoni K et al. Preparation and enhancement of dissolution rate of amlodipine besylate and valsartan using liquisolid technique. Pharmacie Globale (IJCP) 2013: 06(04),1-6.

35. Chella N, Narra N, Rama Rao T. Preparation and characterization of liquisolid compacts for improved dissolution of telmisartan. Journal of drug delivery. 2014;2014(1):692793.

36. Chella N, Shastri N, Tadikonda RR. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. Acta Pharmaceutica Sinica B. 2012 Oct 1;2(5):502-8.

37. Manohar SD, Ramakrishna GA, Bhanudas SR. Formulation and evaluation of liquisolid compact of eprosartan mesylate. World J. Pharm. Res. 2015 Apr 30;4:763-82.

38. Manohar SD, Ramakrishna GA, Bhanudas SR. Formulation and evaluation of liquisolid compact of eprosartan mesylate. World J. Pharm. Res. 2015 Apr 30;4:763-82.

39. Khames A. Formulation and characterization of eplerenone nanoemulsion liquisolids, an oral delivery system with higher release rate and improved bioavailability. Pharmaceutics. 2019 Jan 18;11(1):40.

40. Tiong N,Elkordy AA.Effects of liquisolid formulation on dissolution of Naproxen.Eur J

Pharm Biopharm. 2009:73:373-84.

41. A. V. Yadav et al. Formulation and Evaluation of Orodispersible Liquisolid Compacts of

Aceclofenac Indian J.Pharm. Educ. Res. 2010, 44(3),227-235.

42. Kiran Thadkala et al. Enhancement of Dissolution Rate of Nimesulide by Liquisolid Compaction Technique. International Journal of PharmTech Research.2012,4(3), 1294-1302.

43. Javad Zadeh Y, Siahi-Shadbad MR, Barzegar-Jalali M, Nokhodchi A. Enhancement of dissolution rate of piroxicam using liquisolid compacts. Il Farmaco. 2005 Apr 1;60(4):361-5.

44. Vittal GV, Deveswaran R, Bharath S, Basavaraj BV, Madhavan V. Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design. International journal of pharmaceutical investigation. 2012 Jul;2(3):150.

45. Regu V, Subudhi BB, Swain RP, Bhattacharjee A, Karna N, Khan AS, Nanda N. Formulation Development and Evaluation of Liquisolid Compacts For Ibuprofen Liquisolid Tablets. Journal of Pharmaceutical Negative Results. 2023 Jan 1:559-71.

46. Nazem NM, Shokri J, Nourani N, Zangi AR, Lam M, Nokhodchi A, Javad Zadeh Y. Combining liquisolid and co-grinding techniques to enhance the dissolution rate of celecoxib. Journal of Pharmaceutical Innovation. 2023 Mar;18(1):300-9.

47. The Official Compendia of Standards. United States Pharmacopoeia and National Formulary. Asian Edition. Washington, DC: United States Pharmacopeial Convention, Incorporated; 2000. p. 546-47, 2148-49.

48. Patric JS. Martin’s Physical Pharmacy and Pharmaceutical Sciences. 5th ed. Lippincott Williams and Wilkins; 2003.

49. Manogar PG, Hari BV, Devi DR. Emerging liquisolid compact technology for solubility enhancement of BCS class-II drug. Journal of Pharmaceutical Sciences and Research. 2011 Dec 1;3(12):1604.

50. Hussain Y, Shah MN. Liquisolid Technique: a Novel Tool to Develop Aceclofenac-Loaded Eudragit L-100 and RS-100-Based Sustained Release Tablets. Journal of Pharmaceutical Innovation. 2021 Dec;16:659-71.

51. Kumari N, Mishra S. A review on solubility enhancement by liquisolid technique as a novel approach.

52. T. Guan, Y. Miao, L. Xu, S. Yang, J. Wang, H. He, X. Tang, C. Cai, H. Xu, Injectable nimodipine-loaded nanoliposomes: preparation, lyophilization and characteristics, Int. J. Pharm. 410 (2011) 180–187

53. Bhattacharyya S, Ramachandran D. Solubility enhancement study of lumefantrine by formulation of liquisolid compact using mesoporous silica as a novel adsorbent. Materials Letters: X. 2022 Dec 1;16:100171.

54. Khaled KA, Asiri YA, El-Sayed YM. In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. International journal of pharmaceutics. 2001 Jul 3;222(1):1-6.

55. Nokhodchi A, Hentzschel CM, Leopold CS. Drug release from liquisolid systems: speed it up, slow it down. Expert opinion on drug delivery. 2011 Feb 1;8(2):191-205.

56. Kala NP, Shaikh MT, Shastri DH, Shelat PK. A Review on Liquisolid Systems. Journal of Drug Delivery and Therapeutics. 2014 May 15;4(3):25-31.

57. Madhavi N, Likitha O, Iswariya VT, Swarnalatha KM, Rao TR. A Review on Liqui-Solid Compaction of Solid Dispersion. Journal of Coastal Life Medicine. 2022 Mar 31;10:536-45.

58. Pathak A, Goyal R, Agrawal P, Rajput S, Tiwari G, Shivhare R. A review on liquisolid technology. World J Pharma Res. 2012 Jun 12;1(3):500-12.

59. Badawy MA, Kamel AO, Sammour OA. Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study. Drug Deliv 2016;23:818–827.

60. Ramenskaia GV, Shokhin IE, Savchenko AI, et al. The dissolution test in biorelevant media as a prognostic tool for modeling of drug behavior in vivo. Biomed Khim 2011;57:482–489.

Related Images:

Recent Images

A Review on Diabetes Mellitus: Type1 & Type2

Formulation and Evaluation of Herbal Hair Mask

FT-IR and UV-Vis Spectroscopic studies of Cd(II), Hg(II) and Zn(II) metal complexes of 2-methoxy-2

FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2

Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System

Formulation and Characterisation of Papaya Leaf Gel

Formulation and Characterisation of Herbal Neem Soap

Formulation and Evaluation of Herbal Hair Serum

Pharmaceutical Marketing Role to Adapt Drug Promotional Practices at the duration times of Pandemic Covid-19