ABSTRACT:
The Gastroretentive Drug Delivery System (GRDDS) is an advanced approach for enhancing the oral delivery of drugs by prolonging their retention in the stomach. By extending the stomach residence duration, this approach improves therapeutic efficacy and bioavailability while addressing issues including site-specific drug absorption and restricted bioavailability. Dosage forms are kept in the stomach using a variety of methods, including as floating and non-floating systems, which maximize retention by taking into account characteristics like density, shape, and polymer kinds. Additionally, both synthetic and natural polymers are used in the GRDDS, which affects the therapeutic results and release patterns. GRDDS has drawbacks, such as issues with formulation and appropriateness for specific medications, despite its advantages, which include increased bioavailability and decreased drug waste. These technologies are still being developed in order to get beyond physiological obstacles and enhance the results of oral medication delivery.
Cite this article:
Mansuri Jahid, Rehan Deshmukh, Khan Ramiz.V, Sayyed Anas Ali A Comprehensive Review on Gastro Retentive Drug Delivery System. IJRPAS, Sept – Oct 2024; 3(5): 99-114
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