ABSTRACT:
Herbal medicines have been used for centuries, mostly in oral form. However, oral use often faces problem such as poor absorption, changes in metabolism, and low patient compliance. To solve these issues, a new method called transdermal delivery is being explored. This system delivers herbal cardioprotective compound directly through the skin into the bloodstream. • Herbal bioactives- (such as Terminalia Arjuna, Allium sativum, Ocimum sanctum loaded into nanocarriers for better skin penetration. • Transdermal delivery- to bypass stomach and liver breakdown, ensuring steady drug levels in the blood. • Targeted cardiovascular protection, where the herbal compounds reach the heart and blood vessels directly. This approach represents a promising alternative for safe, long-term management of cardiovascular diseases by integrating traditional herbal knowledge with modern pharmaceutical technology Cradiovascular diseases remain one of the leading causes of mortality worldwide, demanding novel therapeutic strategies with improved safety and efficacy. Herbal medicines, enriched with bioactive phytoconstituents, have gained attention as potential alternative or adjuvants to conventional synthetic drugs due to their cardioprotective, antioxidant, and lipid lowering properties. However, poor oral bioavailability and extensive first pass metabolism limit the therapeutic potential of many herbal compound. Transdermal drug delivery systems provide a promising approach by enabling sustained release, improved patient compliance, and avoidance of gastrointestinal degradation.