ABSTRACT:
Herbal medicines have been used for centuries, mostly in oral form. However, oral use often faces problem such as poor absorption, changes in metabolism, and low patient compliance. To solve these issues, a new method called transdermal delivery is being explored. This system delivers herbal cardioprotective compound directly through the skin into the bloodstream.
• Herbal bioactives- (such as Terminalia Arjuna, Allium sativum, Ocimum sanctum loaded into nanocarriers for better skin penetration.
• Transdermal delivery- to bypass stomach and liver breakdown, ensuring steady drug levels in the blood.
• Targeted cardiovascular protection, where the herbal compounds reach the heart and blood vessels directly.
This approach represents a promising alternative for safe, long-term management of cardiovascular diseases by integrating traditional herbal knowledge with modern pharmaceutical technology
Cradiovascular diseases remain one of the leading causes of mortality worldwide, demanding novel therapeutic strategies with improved safety and efficacy. Herbal medicines, enriched with bioactive phytoconstituents, have gained attention as potential alternative or adjuvants to conventional synthetic drugs due to their cardioprotective, antioxidant, and lipid lowering properties. However, poor oral bioavailability and extensive first pass metabolism limit the therapeutic potential of many herbal compound. Transdermal drug delivery systems provide a promising approach by enabling sustained release, improved patient compliance, and avoidance of gastrointestinal degradation.
Cite this article:
Pandit Tanuja Tejraj, Miss. Meera Deokar.Cardiovascular Targeted Herbal Delivery Via Skin using Herbal Patches: A Comprehensive Review. IJRPAS, November 2025; 4(11): 10-22.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.41102
1.
Cheng YC.
Transdermal delivery systems of natural products applied. 2020.
2.
Wong WF. Recent
advancement of medical patch for transdermal delivery. 2023.
3.
Monton C. Herbal
transdermal patches made from optimized polyvinyl alcohol. 2022.
4.
Das R,
Chakraborty S. Intrusion of herbal antilipidemics – cardiac protective through
electromagnetic thermal device patches.
Cardiol Cardiovasc Res. 2017.
5.
Isopencu GO.
From plants to wound dressing and transdermal delivery system. 2023.
6.
Bharti R, Singh
B, Kaur G. Transdermal drug delivery: a novel approach to herbal formulation
for cardiovascular diseases. J Herbal Med. 2022;30(40):100456.
7.
Khan MS, Ahmad
F, Ansari WA. Herbal intervention in cardiovascular disorders: mechanistic
insight and future prospects. Phytomedicine. 2021;85:153557.
8.
Patel A,
Prajapati V, Tripathi P. Transdermal patches: a promising approach for herbal
drug delivery. Int J Pharm Sci Res. 2020;11(30):1005–1050.
9.
World Health
Organization. Cardiovascular diseases: fact sheet. Geneva: WHO; 2023.
10. Gupta R, Sharma V. Nanoformulations of herbal agents
for cardiovascular targeting: emerging trends and challenges. Drug Deliv Lett.
2021;11(2):150–154.
11. Chen J, et al. Recent advancement of medical patches
for transdermal drug delivery. 2023.
12. Otrisal P, et al. From plants to wound dressing and
transdermal delivery of herbal-based products. 2023.
13.
Lamek R, et al.
Transdermal drug delivery systems: methods for enhancing skin permeability.
2025.