ABSTRACT:
Topical delivery in cosmetic formulations is a vital strategy for targeted action, enhanced efficacy, and consumer satisfaction. However, the outermost barrier of the skin, the stratum corneum, limits the effective penetration of active cosmetic agents. Consequently, enhancing skin penetration and bioavailability of these actives remains a significant challenge and focus of innovation in cosmeceutical research. This review explores current advances in formulation technologies and strategies aimed at improving the delivery of cosmetic actives through the skin. It covers the role of various carriers such as liposomes, nanoemulsions, solid lipid nanoparticles (SLNs), and microneedles, which have shown promise in overcoming skin barriers and achieving localized and systemic effects. Furthermore, the article discusses the influence of excipients, pH, and formulation viscosity on skin absorption. Attention is given to the regulatory considerations and safety concerns associated with advanced topical systems. Emphasis is also placed on recent in-vitro and in-vivo models used to evaluate penetration and bioavailability. By critically analyzing technological advancements and emerging delivery platforms, this review provides insight into the future landscape of topical cosmetic delivery and its potential to revolutionize skincare efficacy.