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Author(s): Sneha Pandey1, Vipin Kumar2, Shabnam Ain*3, Qurratul Ain4, Babita Kumar5, Nidhi Ruhela6, Bhuvnesh7

Email(s): 1shabnam.ain@sanskar.org, 2

Address:

    Sanskar College of Pharmacy and Research, Ghaziabad, Uttar Pradesh 201302, India

Published In:   Volume - 4,      Issue - 2,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4202  

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ABSTRACT:
Alzheimer’s disease (AD) is a neurodegenerative disease causing cognitive decline, language deficits, and difficulty performing daily tasks. With 44 million people affected, it doubles every five years beyond 65. The exact cause is unknown, but hypotheses suggest Amyloid plaques outside the neuron cell or Neurofibirlin tangles inside the neuron. AD is more common in women and is caused by decreased estrogen levels after menopause, oxidative stress, excytotoxicity, environmental factors, and decreased Ach levels. Current treatments include Aducanumab and Lecanemab, but future therapies include disease-modifying therapies, stem cell therapy, monoclonal antibodies, gene therapy, and natural compound treatment. This research aims to investigate the role of biomarkers, advanced imaging techniques, lifestyle adjustments, and emerging treatments in the early detection and treatment of Alzheimer’s disease (AD). The objectives include exploring the pathophysiology of AD, evaluating diagnostic methods, and assessing the efficacy and safety of current and investigational treatments.

Cite this article:
Sneha Pandey, Vipin Kumar, Shabnam Ain, Qurratul Ain, Babita Kumar, Nidhi Ruhela, Bhuvnesh. Alzheimer’s Disease: An Overview IJRPAS, Feb 2025; 4 (2): 13-32.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4202


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