Abstract View

Author(s): Vastavi Gore* and Dr. Anant Kumar Patel1

Email(s): 1vastavigore17@gmail.com

Address:

    College of Pharmacy, Swami Vivekanand Group of Institutions, Indore (Madhya Pradesh), India.

Published In:   Volume - 4,      Issue - 3,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4302  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
Imperata cylindrica roots, known for their diuretic, and anti-inflammatory properties in traditional medicine, were analyzed for phytochemical constituents. This study evaluated the antidepressant like effects of I. cylindrica root extract using animal models like Forced Swim Test and Tail Suspension Test on swiss albino mice. The experimental groups comprised a control group (distilled water), a standard drug group (Fluoxetine 25 mg/kg), and three test groups receiving root extract doses (250 mg/kg, 500 mg/kg and1000 mg/kg, p.o). The root extract of I. cylindrica significantly reduced immobility duration in the test groups, suggesting potential therapeutic applications for depressive disorders.

Cite this article:
Vastavi Gore and Dr. Anant Kumar Patel. Evaluation of Anti-depressant activity of Imperata cylindrica Roots Extract in swiss albino mice. IJRPAS, March 2025; 4 (3): 13-20.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4302


  Lalthanpuii PB, Zarzokimi, Lalchhandama K. Some phytochemical analyses of different extracts of the cogon grass Imperata cylindrica from Mizoram, India. Sci Vis. 2018 Dec; 18(4):120-124.

2.        Lalthanpuii PB, Lalchhandama K. Phytochemical analysis and in vitro anthelmintic activity of Imperata cylindrica underground parts. BMC Complementary Medicine and Therapies (2020) 20:332.

3.        Jung, Y.-K.; Shin, D. Imperata cylindrica: A Review of Phytochemistry, Pharmacology, and Industrial Applications. Molecules 2021, 26, 1454. Available from: https://doi.org/ 10.3390/molecules26051454

4.        Sulistyowati E, Aziz MR. Systematic literature review: potential anti-hyperglycaemia Imperata cylindrica. Bali Medical Journal 2022; 11(2): 752-756.

5.        Sharma A, Kaur S and Shri R. Evaluation of antidepressant activity of Chenopodium album extracts and fractions in mice. IJPSR. 2021; 12(5): 2707-2715.

6.        Bee R, Maheshwari KK. Evaluation of antidepressant activity of Acyranthes aspera by using open field test in rats. World J Pharm Res. 2019; 8(6): 1183-1195.

7.        Kalpana P. Rahate et al. Quantitative estimation of tannins, phenols, and antioxidant activity of the methanolic extract of Imperata cylindrica. Int J Res Pharm Sci. 2013; 4(1): 73-77.

8.        Konan, A.M.L., Golly, K.J., Kra, A.K.M., Adima, A.A. and Lohoues, E.E.C. (2022) Phytochemical Screening and Toxicity Assessment of Imperata cylindrica (L.) P. Beauv. (Poaceae) Raw Extracts with Brine Shrimp (Artemia salina) Lethality Assay. Journal of Biosciences and Medicines, 10, 153-171.

9.        Yadav RNS, Agarwala M. Phytochemical analysis of some medicinal plants. J Phytol. 2011; 3(12): 10-14.

10.    Çilesizoğlu NB, Yalçin E, et al. Qualitative and quantitative phytochemical screening of Nerium oleander L. extracts associated with toxicity profile. Sci Rep. 2022; 12: 21421.

11.    OECD Guideline for the Testing of Chemicals (2001). Acute Oral Toxicity – Up-and-Down Procedure (Test No. 425). OECD Publishing.

12.    Udyavar S et al. Evaluation of antidepressant activity of ethanolic extract of Mimosa pudica in swiss albino mice. Indian J Pharm Pharmacol. 2020; 7(4):240-244.  

Related Images:



Recent Images



Nanotechnology in Cosmetic Formulations: Recent Advances and Safety Concerns
Analysis of Pro-Inflammatory Cytokines Response Among Typhoid Patients Co-Infection with Plasmodium falciparum In Khartoum State -Sudan
Optimizing OEL and ADE/PDE Compliance in Pharma
Formulation and Evaluation of Quercetin Nanoemulsion Gel for Rheumatoid Arthritis
Formulation and Evaluation of Herbal Oil -Roghan-e-Turb: A Traditional Unani Formulation for Analgesic Activity
Formulation and Evaluation of Anti-Pimple Herbal Serum Enriched with Tulsi, Turmeric, Aloe Vera, Neem
Formulation, Optmization and Evaluation of Curcuma longa and Piper nigrum Hydrogel
A Review on Emerging Technologies in Monitoring and Diagnosing Immune Thrombocytopenia (ITP): Current Trends and Future Directions
Phytochemical Characterisation, In Silico Androgen Receptor Inhibitory Activity, and Fertility-Enhancing Potential of Aqueous–Ethanol Root Extract of Triclisia subcordata Oliv.
Formulation of Effervescent Granules from Bangkal Tree (Nauclea orientalis) Leaf Extract: A Potential  Larvicide Against Aedes Aegypti

Tags