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Author(s): Vastavi Gore* and Dr. Anant Kumar Patel1

Email(s): 1vastavigore17@gmail.com

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    College of Pharmacy, Swami Vivekanand Group of Institutions, Indore (Madhya Pradesh), India.

Published In:   Volume - 4,      Issue - 3,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4302  

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ABSTRACT:
Imperata cylindrica roots, known for their diuretic, and anti-inflammatory properties in traditional medicine, were analyzed for phytochemical constituents. This study evaluated the antidepressant like effects of I. cylindrica root extract using animal models like Forced Swim Test and Tail Suspension Test on swiss albino mice. The experimental groups comprised a control group (distilled water), a standard drug group (Fluoxetine 25 mg/kg), and three test groups receiving root extract doses (250 mg/kg, 500 mg/kg and1000 mg/kg, p.o). The root extract of I. cylindrica significantly reduced immobility duration in the test groups, suggesting potential therapeutic applications for depressive disorders.

Cite this article:
Vastavi Gore and Dr. Anant Kumar Patel. Evaluation of Anti-depressant activity of Imperata cylindrica Roots Extract in swiss albino mice. IJRPAS, March 2025; 4 (3): 13-20.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4302


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4.        Sulistyowati E, Aziz MR. Systematic literature review: potential anti-hyperglycaemia Imperata cylindrica. Bali Medical Journal 2022; 11(2): 752-756.

5.        Sharma A, Kaur S and Shri R. Evaluation of antidepressant activity of Chenopodium album extracts and fractions in mice. IJPSR. 2021; 12(5): 2707-2715.

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7.        Kalpana P. Rahate et al. Quantitative estimation of tannins, phenols, and antioxidant activity of the methanolic extract of Imperata cylindrica. Int J Res Pharm Sci. 2013; 4(1): 73-77.

8.        Konan, A.M.L., Golly, K.J., Kra, A.K.M., Adima, A.A. and Lohoues, E.E.C. (2022) Phytochemical Screening and Toxicity Assessment of Imperata cylindrica (L.) P. Beauv. (Poaceae) Raw Extracts with Brine Shrimp (Artemia salina) Lethality Assay. Journal of Biosciences and Medicines, 10, 153-171.

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12.    Udyavar S et al. Evaluation of antidepressant activity of ethanolic extract of Mimosa pudica in swiss albino mice. Indian J Pharm Pharmacol. 2020; 7(4):240-244.  

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