Abstract View

Author(s): Tandale A.S1, Dr.Rahane R.D2, Dhone P.S*3, Pawar A.R4, 5, Pawade K.S6, Lakule S.D.7

Email(s): 1pratikdhone8888@gmail.com

Address:

    Matoshri Miratai Aher College Of Pharmacy, Karjule Harya.

Published In:   Volume - 4,      Issue - 3,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4320  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
Surprisingly, digitalis, a plant-based steroid, is used to treat cardiac arrhythmia, chronic failure (CHF), and reentrant supraventricular tachycardia. Digitalis has a beneficial inotropic effect on the center muscle. A chemical known as an associate degree inotrope is one that could directly affect contraction. inhibition of the membrane-bound ATPase (Na +/K + -) sodium- and potassium-activated nucleoside triphosphatase, which raises the concentration of the metal calcium ([Ca 2+]) in living organisms. Digoxin's pharmacology is the main topic of this essay.

Cite this article:
Tandale A.S, Dr.Rahane R.D, Dhone P.S*, Pawar A.R, Pawade K.S, Lakule S.D. A Review on Digitalis in Congestive Heart Failure. IJRPAS, March 2025; 4 (3): 146-154. https://doi.org/10.71431/IJRPAS.2025.4320DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4320


  Dr.B.Anil Reddy Maheshwara College of Pharmacy, Department of Pharmaceutical sciences, Hyderabad, Andhra Pradesh, Volume-3

2)      Gheorghiade M, Van Veldhuisen DJ, Colucci WS. Contemporary use of digoxin in the

management of cardiovascular disorders. Circulation 2006;113:2556–2564. https://doi.

org/10.1161/CIRCULATIONAHA.105.560110

3)      Bavendiek U, Davilla LA, Koch A, Bauersachs J. Assumption versus evidence: the case of digoxin in atrial fibrillation and heart failure. Eur Heart J 2017;38:2095–2099.

4)      Buckalew, V.M (2005). Endogenous digitalis-like factors. An historical overview. Front Biosci 1,Vol.0:2325-2334.

5)      McGuffin M, Hobbs C, Upton R, Goldberg A,eds (1997). American Herbal Products Association's Botanical Safety Handbook.Boca Raton, FL: CRC Press.

6)      Shumaik GM, Wu AW, Ping AC (1988). Oleander poisoning: treatment with digoxin-specific Fab antibody fragments. Ann Emerg Med. Vol.17:732-735.

7)      Dick M, Curwin J, Tepper D (1991). Digitalis intoxication recognition and management. J Clin Pharmacol .Vol.31:444-447.

8)      Buckalew, V.M (2005). Endogenous digitalis-like factors. An historical overview. Front Biosci 1,Vol.0:2325-2334.

9)      Dec GW (2003). Digoxin remains useful in the management of chronic heart failure. Med Clin North Am .Vol.87:317

10)  Wickersham RM, Novak K (2004), managing eds. Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons

11)  Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Cleason P(2001). Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. Vol. 12:475-483

12)  Kotecha D, Bunting K, Gill SK, Mehta S, Stanbury M, Jones JC, et al. For the RATE-HF team. Effect of digoxin vs. bisoprolol for heart rate control in atrial fibrillation on patient-reported quality of life. The RATE-HF randomized clinical trial. JAMA 2020; 324:2497–2508. https://doi.org/10.1001/jama.2020.23138

13)  Van Veldhuisen DJ. Low-dose digoxin in patients with heart failure: less toxic and at least as effective? J Am Coll Cardiol 2002;39:954–956. https://doi.org/10.1016/S0735-1097(02) 01710-2

14)  Litovitz TL, Klein-Schwartz W, White S, Cobaugh DJ, Youniss J, Drab A, et al. 1999 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med., 2000 Sep; 18(5): 517-74.

15)  Mutnick AH. Digoxin. In G. E. Schumacher (Ed.), Therapeutic drug monitoring (469–491). Norwalk: Appleton & Lange, 1995.

16)  Pfeffer MA, Swedberg K, Granger CB, Held P, McMurray JJ, Michelson EL,Olofsson B, Ostergren J, Yusuf S, Pocock S; CHARM Investigators and Committees.Effects of candesartan on mortality and morbidity in patients with chronic heartfailure: the CHARM-Overall programme. Lancet 2003; 362: 759-66.

17)  Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B; EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011; 364: 11-21.

18)  Ziff OJ, Lane DA, Samra M, Griffith M, Kirchhof P, Lip GYH, Steeds RP, Townend J, Kotecha D. Safety and efficacy of digoxin: systematic review and meta-analysis of observational and controlled trial data. BMJ 2015;351:h4451.

19)  Ather S, Peterson LE, Divakaran VG, Deswal A, Ramasubbu K, Giorgberidze I, Blaustein A, Wehrens XHT, Mann DL, Bozkurt B. Digoxin Treatment in Heart Failure - Unveiling Risk by Cluster analysis of DIG data. Int J Cardiol 2011; 150:264-269.

20)  Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B; EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med 2011; 364: 11-21.

21)  Remme WJ, Swedberg K. On behalf of the task force for the diagnosis and treatment of chronic heart failure, European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure. Eur Heart J 2001;22:1527–1560. https://doi.org/10. 1053/euhj.2001.2783

22)  Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of serum digoxin concentration and outcome in patients with heart failure. JAMA 2003;289: 871–878. https://doi.org/10.1001/jama.289.7.871

23)  Bavendiek U, Davilla LA, Koch A, Bauersachs J. Assumption versus evidence: the case of digoxin in atrial fibrillation and heart failure. Eur Heart J 2017;38:2095–2099.

 

 

Related Images:



Recent Images



A Review on Diabetes Mellitus: Type1 & Type2
Formulation and Evaluation of Herbal Hair Mask
FT-IR and UV-Vis Spectroscopic studies of Cd(II), Hg(II) and Zn(II)  metal complexes of 2-methoxy-2
FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2
Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System
A Review on Antiseptic Gargle
Formulation and Characterisation of Papaya Leaf Gel
Formulation and Characterisation of Herbal Neem Soap
Formulation and Evaluation of Herbal Hair Serum
Pharmaceutical Marketing Role to Adapt Drug Promotional Practices at the duration times  of Pandemic Covid-19

Tags


Recomonded Articles:

Author(s): Nand Kishore Morampudi; Sarada Akula

DOI:         Access: Open Access Read More

Author(s): Tandale A.S; Dr.Rahane R.D; Dhone P.S*; Pawar A.R,;Pawade K.S; Lakule S.D.

DOI: https://doi.org/10.71431/IJRPAS.2025.4320         Access: Open Access Read More