International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Evaluation of In-vitro Anti-arthritic activity in Methanol and Acetone Extract of Stem of Cissus quadrangularis

Author(s): Dr. Sundhararajan R1, A. Dhanalakshmi*2, Latha. S3, Lokesh. S4, Manibharathi. K5, Megala. S6, Mohamed Adhil. A7

Email(s): 1dhanaanbu26@gmail.com

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    Mohammad Sathak A.J. College of Pharmacy, Chennai, Tamil Nadu.

Published In:   Volume - 4,      Issue - 3,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4312  

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ABSTRACT:
Anti-arthritic activity of Cissus quadrangularis was studied by two methods 1.Inhibition of Albumin denaturation. 2.Human red blood cell membrane (HRBC) stabilization. Egg white denaturation is a process where egg whites experience auxiliary alter and lose their ordinary work due to provocative response, the discharge of incendiary go-betweens disturbs its sensitive structure and hindrance of egg whites denaturation appears the anti-inflammatory action of Cissus quadrangularis . Human red blood cell membrane crack and discharges hemoglobin due to hypotonic condition which is due to incendiary response and stabilization of the layer appears the anti-inflammatory action of the Cissus quadrangularis . As the concentration of the denatured egg whites protein and concentration of film lysis increments the absorbance esteem increments; denaturation of egg whites protein and layer lysis is due to provocative response and discharge of provocative go-betweens. After expansion of the Cissus quadrangularis stem extricate to the test at that point the absorbance esteem diminishes because of the anti-inflammatory movement of the extricate which decreases the egg whites denaturation and membrane lysis.[4,5,6]

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Cite this article:
Dr. Sundhararajan R, A. Dhanalakshmi, Latha. S, Lokesh. S, Manibharathi. K, Megala. S, Mohamed Adhil. A. Evaluation of In-vitro Anti-arthritic activity in Methanol and Acetone Extract of Stem of Cissus quadrangularis. IJRPAS, March 2025; 4 (3): 89-94.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4312


01.     A Review on  Cissus quadrangularis  by Ayesha Siddiqua and Sirisha Mittapally

02.     Cissus quadrangularis : A Medicinal plant with diverse pharmacological activity by Mahek Sharan, Shivsngi Pandey, Dr. Yamini Dixit.

03.     In vitro Anti-arthritic activity of  Cissus quadrangularis  stem extract by Vaijayanthimala p, Sakthipriya M, Sangameswaran B.

04.     Mizushima, Y and Kobayashi, M. Interaction of anti-inflammatory drugs with serum proteins, especially with some biologically active proteins. J Pharma Pharmacol 1968; 20:169-173.

05.     Sakat, S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. International Journal of Pharma and Pharmacological Sciences 2010; 2(1):146-155.

06.     Kumar V, Bhat ZA, Kumar D, Bohra P, Sheela S. In vitro anti-inflammatory activity of stem extract of  Cissus quadrangularis  of Basella alba linn. var. alba. Int J Drug Dev Res 2011; 3(2): 176-9

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