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Author(s): Edwin Dias11, 2*2, Riya Fathima V33

Email(s): 1dredwindias@gmail.com

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    1. HOD and Professor, Department of Paediatrics, Srinivas institute of medical science and research centre, Manglore, Karnataka, India 2. Adjunct Professor, Srinivas University, Director of research and publication, India 3. Final year PharmD student, Srinivas college of pharmacy, Valachil, Manglore, Karnataka, India

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4606  

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ABSTRACT:
Demyelinating diseases of the central nervous system, such as multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and acute disseminated encephalomyelitis (ADEM), represent a broad spectrum of neuroinflammatory disorders. These conditions involve immune-mediated destruction of myelin, leading to substantial neurological dysfunction. Pediatric presentations are often more aggressive, yet the long-term prognosis may differ from adult-onset disease. The treatment landscape has transformed dramatically over the past decade, spurred by discoveries into immunological systems and improved medication development. Using data from clinical trials and real-world applications, this study gathers and evaluates new and existing pharmacologic treatments for demyelinating disorders. It addresses pediatric-specific considerations. It also covers acute treatment strategies, disease-modifying therapies (DMTs), immunosuppressive agents, dosing, route of administration, adverse drug reactions, dose adjustments, and necessary lifestyle modifications.

Cite this article:
Edwin Dias, Riya Fathima V. A Comprehensive Review on Pharmacological Management of Paediatric Demyelinating Disorders. IJRPAS, June 2025; 4 (6): 63-68.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4606


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