International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

Abstract View

Phytochemical Screening, Formulation and Evaluation of Leaf Extract of Leucas aspera and Leucas indica by Using Analytical Methods

Author(s): Kota. Venkata Swapna1, Ankala. Gurulakshmi2, Gudimallam. Sai Sowmya3, Kande.Himabindu Bai4, Kokati. Keerthi5, Kotakonda. Aswani6

Email(s): 1vswapnayadav19@gmail.com

Address:

    Swathi College of Pharmacy, Venkatachalam, Nellore. 524320.

Published In:   Volume - 4,      Issue - 7,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4708  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
The present study focuses on the formulation and evaluation of herbal tablets using the dried leaf powder of Leucas aspera and Leucas indica, two medicinal plants known for their antimicrobial, anti-inflammatory, and antioxidant properties. Three tablet formulations (F1, F2, and F3) were prepared using the wet granulation method, incorporating different binding agents—1% sodium alginate (F1), 1% acacia (F2), and 1% HPMC-10 (F3). The prepared tablets were subjected to various physicochemical evaluation parameters including general appearance, weight variation, hardness, thickness, friability, and disintegration time. All formulations exhibited acceptable physical characteristics within pharmacopeial limits. F1 showed the fastest disintegration time (4.5 minutes), indicating suitability for immediate-release formulations. F2 demonstrated balanced properties with moderate disintegration (6.2 minutes) and good mechanical strength. F3 had the highest hardness and lowest friability, but exhibited delayed disintegration (7.0 minutes), suggesting potential for sustained-release applications. This study highlights the influence of different binding agents on tablet performance and demonstrates the feasibility of developing standardized herbal tablets from Leucas species. Further studies on in-vitro drug release, stability, and pharmacological activity are recommended to validate their therapeutic potential

Keywords:

Cite this article:
Kota. Venkata Swapna, Ankala. Gurulakshmi, Gudimallam. Sai Sowmya, Kande.Himabindu Bai, Kokati. Keerthi, Kotakonda. Aswani. Phytochemical Screening, Formulation and Evaluation of Leaf Extract of Leucas aspera and Leucas indica by Using Analytical Methods. IJRPAS, July 2025; 4 (7): 97-103.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4708


1.      Pharmacognostical evaluation of leucas aspera. Nat prod sci.2005 ;11;109 -14.

2.      Shirazi AM. Studies on leucas aspera. Indian J pharm.1947;9:116-7.

3.      Neelesh Babu,Akash,Ajeet Sing,Ramveer Sing and Navneet.therapeutics potential and pharmacological properties of Leucas indica:2018;7(7):564-568

4.      M.Sowjanya,Ch.venkatrayulu,B.V.Sandeep,Vardi Venkateswarlu.In Vitro Antibacterial activity of flower extract of Leucas indica 2023;44(S-3):1290-1293

5.      J.Chetia and L.R.Saika.2020;64(2):96-101

6.      Ganapaty S,.Diuretic, laxative and toxicity studies of Cocculus hirsutus aerial parts. Fitoterapia 2002;73(1):28-31.

7.      Patel et al. 2018.Evaluation of antimicrobial activity of Leucas aspera. Journal of Pharmaceutical Science and Research, 10(10), 2431-2434.

8.      Rao et al.(2019). Phytochemical analysis and antioxident activity of Leucas aspera.Journal of Food Science and Technology, 56(2),631-638

9.      MS Prajapati, Leucas aspera:A review.  Pharmacogn Rev. 2010;(7):85-87.

10.  Neelesh Babu, Therapeutics potential and pharmacological properties of Leucas indica:A review. The pharma Innovation Journal 2018; 7(7):564-568.

11.  Pharmacognostical evaluation of leucas aspera. Nat prod sci.2005 ;11;109 -14.

12.  Patel et al. 2018.Evaluation of antimicrobial activity of Leucas aspera. Journal of Pharmaceutical Science and Research, 10(10), 2431-2434.

13.  M.Sowjanya, Ch.venkatrayulu, B.V.Sandeep,Vardi Venkateswarlu. In Vitro Antibacterial activity of flower extract of Leucas indica 2023;44(S-3):1290-1293

14.  Nipa Chowdhury, Talha Bin Emran. Cytotoxic potential of the ethanolic extract of leucas aspera.2012; 2(2): 87-90

15.  Rajeev Ramachandra, Sajeeda Niketh. Therapeutic properties of extract of leucas aspera and Anisomeles malabarica. 2019: 10(1): 66.3:66.34

Related Images:



Recent Images



Pharmacological Properties of Amomum subulatum Roxb., a Significant Medicinal Herb
Synthesis of Thiourea Derivatives as Bioisosteric Structures of SERMs Pursuant to Virtual Screening
A Narrative Review of the Prevalence, Types, and Contributing Factors of Drug-Related Problems in Hospitals.
A Review on Nature’s Neglected Treasures Unveiling Medicinal Use of Common Weeds in Drug Therapy: A Statistical Survey
Implantable Drug Delivery Systems: A Comprehensive Review with Recent Advancements
Beyond Diarrhea Control: Emerging Neuroimmune and Psychobiotic Roles of Bacillus clausii
Artificial Intelligence-Enabled Quality by Design and Regulatory Science for Apixaban Orodispersible Tablets: A Critical Review of Clinical Rationale, Formulation Strategy, and Submission-Ready Documentation for Stroke Prevention
Analysis of pro inflammatory cytokinse response among hepatitis B patients co-infected with Plasmodium falciparum in Khartoum state, Sudan
Dual Incretin Agonism in Type 2 Diabetes and Obesity: Systematic Review of Tirzepatide Mechanisms and Clinical Outcomes
Green Synthesized Zinc Oxide Nanoparticles from Mimusops elengi Flowers: UV Characterization and Antidiabetic Potential

Tags


Quick Links


Latest Issues

Popular Articles