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International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544 | Issues per year: Monthly | Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Formulation and Evaluation of Nasal Microspheres

Author(s): Mr. Prajwal Gajanan Nakat¹, Dr. Nitin S. Bhajipale², Prof Dr. Manish R. Bhise³

Email(s): ¹prajwalnakat7@gmail.com

Address:

S.G.S.P.S. Institute of Pharmacy Kaulkhed, Akola–444004, (MH) India.

Published In: Volume - 4, Issue - 8, Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4802

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ABSTRACT:
The present research focuses on the formulation and evaluation of nasal microspheres of rivastigmine, an cholinesterase inhibitors, designed to enhance patient compliance and provide rapid therapeutic action. nasal microspheres offer a convenient and effective drug delivery system, Nasal microspheres of rivastigmine are primarily beneficial for patients with mild to moderately severe Alzheimer's disease or dementia associated with Parkinson's disease. In this study, various formulations were developed using HPMC and Carbopol polymer, nasal microspheres were prepared by emulsion solvent evaporation method using HPMC and Carbopol polymer at different drug to polymer ratio. Total six formulations (F1 to F6) was prepared using different concentration of polymer. Accurately weighted amount of the polymers Carbopol and HPMC and excipients to ensure desirable mechanical properties and Rapid drug absorption, quick onset of action and prolonged release period. The prepared microspheres were evaluated for physical appearance, thickness, weight uniformity, drug content and In-vitro mucoadhesion study. Among all formulations, the batch F6 exhibited optimal performance, offers a promising platform for nasal drug delivery. It demonstrated High drug entrapment efficiency and drug content, Excellent mucoadhesive properties, Sustained drug release for up to 12 hours, Favourable zero-order kinetics indicating controlled release and Stability under accelerated conditions, making it a promising candidate for improving bioavailability and onset of action. This investigation highlights the potential of nasal microspheres as a patient-friendly alternative to conventional dosage forms for the management of Alzheimer's disease or dementia associated with Parkinson's disease.

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Cite this article:
Mr. Prajwal Gajanan Nakat, Dr. Nitin S. Bhajipale, Prof Dr. Manish R. Bhise. Formulation and Evaluation of Nasal Microspheres. IJRPAS, August 2025; 4 (8): 17-35.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4802

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