ABSTRACT:
While oral dosage forms have some limitations compared to other methods, such as concerns about drug absorption, these issues can be mitigated by offering medications in liquid form, which may allow for lower dosages. Oral forms of medication are the most commonly used, but the volatility of some drugs in liquid form can restrict their application. Effervescent granules or tablets, created from a combination of sodium bicarbonate, citric acid, and tartaric acid, react with water to release carbon dioxide, resulting in effervescence. These effervescent forms have various everyday applications. Despite their drawbacks, including the potential for absorption issues, oral dosage forms remain the predominant method of drug delivery, enabling widespread use of these formulations.
Cite this article:
Mohammad Vakar, Shaikh Imran Kalam, Dr. G.J. Khan, M Sohil M Shabbir, Aman Shaikh, Shaikh Md. Moiz. Effervescent Tablets. IJRPAS, 2024; 3(6): 90-99.
1. Bhavana Dnyandeo Tambe, Formulation and Evaluation of Paracetamol Effervescent Tablet, Research Article, Asian Journal of Pharmaceutical Research and Development. 2021; 9(4): 47-51.
2. Apeksha B. Korde, Suvarna N. Waghmare, Sujata S. Bote, Rohini S. Palekar and Priti B. Ghumre,Formulation And Evaluation of Paracetamol Effervescent Tablet. AResearch Article: WJPR,Volume 10, Issue 8, 1062-1072.
3. Sangram Biranje, Akshata More, Trusha P. Shangrapawar, Ashok Bhosale, A Review onFormulation and Evaluation of Effervescent Tablet, Review Article, IJPPR, June 2021 Vol.:21,Issue:3.
4. Kalyani Waghchoure, A Review on: Effervescent Tablet, IJPRA, Volume 8, Issue 1 JanFeb 2023,pp: 1246-1255.
5. Gharti KP, Thapa P, Budhathoki U, Bhargava A, Formulation and in vitro evaluation of floating tablets of hydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug, Journal of Young Pharmacists, 2009; 4(4):201-208.
6. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention, Journal of Controlled release, 2000; (63):235–59.
7. Gharti KP, Thapa P, Budhathoki U, Bhargava A, Formulation and in vitro evaluation of floating tablets ofhydroxypropyl methylcellulose and polyethylene oxide using ranitidine hydrochloride as a model drug, Journal of Young Pharmacists, 2009; 4(4):201-208.
8. Singh BN, Kim KH, Floating drug delivery systems: an approach to oral controlled drug delivery viagastric retention, Journal of Controlled release, 2000; (63):235–59.
9. Singh LP, Rajesh KS, Umalkar DG, Chauhan VK, Rana VK, Vasava KS, Floating Effervescent Tablet: AReview, Journal of pharmaceutical and biomedical sciences, 2011; 5(11):1-6.
10. K. Bala Krishna, “A Review on Effervescent Tablets”, International Journal of Pharmacy &Technology, March, 2011; 3(1): 704-712
11. S.B. Shirsand, “Formulation Design and Optimization of Fast Disintegrating Lorazepam Tablets byEffervescent Method”, Indian Journal of Pharmaceutical Sciences, Jul-Aug, 2010; 72(4): 431-436
12. Vakh, C.; Pochivalov, A.; Andruch, V.; Moskvin, L.; Bulatov, A. A Fully Automated Effervescence-AssistedSwitchable Solvent-Based Liquid Phase Microextraction Procedure: Liquid Chromatographic Determination of Ofloxacin in Human Urine Samples. Anal. Chim. Acta 2016, 907, 54–59.
13. Sallam A, Bioequivalence of Two Oral Formulations of Modafinil Tablets in Healthy Male Subjects under Fed and Fasting Conditions.Journal of Bioequivalence Availability. 2015; 7:63-67
14. Leon Lachman, Herbert A. Lieberman , Joseph L. Kanig: The theory and practice of Industrial Pharmacy, Varghese publication house, 3rdedition , 1990, 293-373.
15. Herbert A. Liberman, Martin M. Rieger and Gilbert S. Banker , pharmaceutical dosage forms: Tablets ; volume 1.
16. Howard CA, Lloyd A, Nocholas and Popovich, “Effervescent granules”8th edition “Pharmaceutical Dosage from and Drug Delivery “International Student Edition. -2000, 172-178.
17. Abolfazl A, Formulation, Characterization and Physicochemical Evaluation of Ranitidine Effervescent Tablets, Advanced PharmaceuticalBulletin, 2013; 3(2): 315322
18. Shankrayya .M , Tejashwini. J M, Chaithra. D, Venkatesh .J. S. Formulation And Evaluation ofLafutidine Effervescent Tablets. Indo American Journal of Pharmaceutical Research.2021:11(10)
19. Somayeh Taymouria, Abolfazl Mostafavib, Hamid Mahmoodib, Formulation, Design, and Optimization of Taste Masked Effervescent Tablet Containing Methocarbamol, Iranian Journal of Pharmaceutical Sciences 2021: 17 (4): 1-14
20. Bharat sagare , Vishal Pawar , Mansi Patilghote3 , Shamlila B Bavge, Nandkishor B Bavge, Evaluation of Marketed Effervescent Tablets, IJIRT Volume 8 Issue 8 ISSN: 2349-6002
21. Vergeire DG, Usefulness of Cost Effectiveness: Evidence versus Applicability. Pharm Anal Acta, 2016; 7:456.
22. Wang C, Application of In Vitro Models in Developmental Neurotoxicity and Pharmaceutics Resea rch, Journal of Molecular Pharmaceutics & Organic Process Research, 2015;3:122-128.