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Author(s): Krushna A. Zagade*1, Shaikh Usman M.2, Panchal Krushna S.3, Wavhale Sharda S.4, Dr. R. D. Ingole5

Email(s): 1krushanazagade@gmail.com

Address:

    DJP’S College Of Pharmacy, At. Pohetakli, Tq. Pathri, Dist. Parbhani – 431506, Maharashtra, India

Published In:   Volume - 4,      Issue - 5,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4508  

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ABSTRACT:
Cough is a common health issue affecting people of all ages and is often treated using over-the-counter syrups. Most conventional cough syrups act by suppressing the brain’s cough reflex but can lead to side effects such as drowsiness, constipation, difficulty in breathing, addiction, and in some cases, death. Due to these risks, many people are turning to safer, natural alternatives. Ayurvedic medicine, which uses herbs and natural ingredients, is gaining popularity as a more suitable option for cough relief. Herbal cough syrups are especially favored because they are easy to consume and generally well tolerated. This study focuses on the preparation and evaluation of an herbal cough syrup made with traditional ingredients such as licorice, Tulsi, cinnamon, ginger, clove, and honey. These herbs are known for their soothing and medicinal properties in treating respiratory conditions. The syrup was formulated in a laboratory and tested for pH, viscosity, density, and stability to ensure quality. The results showed that the herbal formulation was stable and had good physical characteristics. Additionally, antitussive activity was tested, and the herbal syrup demonstrated better cough relief at a lower dose compared to a standard allopathic medicine. These findings support the potential of herbal syrups as effective and safer alternatives for managing both dry and wet coughs. With increasing awareness about the side effects of chemical drugs, herbal formulations provide a promising option for natural, side-effect-free cough treatment.

Cite this article:
Krushna A. Zagade*, Shaikh Usman M., Panchal Krushna S., Wavhale Sharda S., Dr. R. D. Ingole. Formulation and evaluation of polyherbal cough syrup. IJRPAS, May 2025; 4 (5): 76-91.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4508


1] Cragg GM, Newman DJ. International collaboration in drug discovery and development from natural sources. Pure Appl Chem. 2005;77(11):1923–42.

2 ]Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz J Med Biol Res. 2000;33(2):179–90.

3] Chung KF, Pavord ID. Prevalence, pathogenesis, and causes of chronic cough. Lancet. 2008;371(9621):1364–74.

4] Aliprandi P, Cima L, Carrara M. Therapeutic use of levodropropizine as an antitussive agent. Clin Drug Investig. 2002;22(4):209–20.

5] Calixto JB. Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents). Braz J Med Biol Res. 2000;33(2):179–90.

6] Thompson M, Vodicka TA, Blair PS, Buckley DI, Heneghan C, Hay AD. Duration of symptoms of respiratory tract infections in children: systematic review. BMJ. 2013 Dec 11;347:f7027. doi: 10.1136/bmj.f7027.

7] Kokate CK, Gokhale SB, Purohit AP. A Text Book of Pharmacognosy. 8th ed. Pune: Nirali Prakashan; 2008. p. 9–166.

8] Azwanida NN. A review on the extraction methods used in medicinal plants: principle, strength, and limitation. Med Aromat Plants. 2015;4(3):196. doi:10.4172/2167-0412.1000196.

9] Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–8. doi:10.38124/IJISRT20JUN334.

10] Harris K. When a cough may be more than just a cough. OSF HealthCare. 2021 Jan 25. Available from: https://www.osfhealthcare.org/blog/when-a-cough-may-be-more-than-just-a-cough

11] Sultana S, Khan A, Safhi MM, Alhazmi HA. Cough suppressant herbal drugs: a review. Int J Pharm Sci Invention. 2016;5(5):15–28.

12] Chung KF, Pavord ID. Prevalence, pathogenesis, and causes of chronic cough. Lancet. 2008 Apr 19;371(9621):1364–74.

13] Herbycin. Types of coughs. Herbycin. 2020 Apr. Available from: https://www.herbycin.com/types-of-coughs

14] Vaishnav KB. Diagnostic approach to cough. J Assoc Physicians India. 2013;61: [page numbers]. Available from: https://www.japi.org

15] Nancy choi MD, Tim Newman, "All about Coughs and their causes", 2017

16] Kokate CK, Gokhale SB, Purohit AP. A Text Book of Pharmacognosy. 8th ed. Pune: Nirali Prakashan; 2008. p. 118.

17] Patil AG, Mirajakar KG, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–8. doi:10.38124/IJISRT20JUN334. Available from: ijisrt.com

18] Kokate CK, Gokhale SB, Purohit AP. A Text Book of Pharmacognosy. 8th ed. Pune: Nirali Prakashan; 2008. p. 118.

19]  Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–8. doi:10.38124/IJISRT20JUN334. Available from: https://ijisrt.com/formulation-and-evaluation-of-ginger-macerated-honey-base-herbal-cough-syrup .

20] Kokate CK, Gokhale SB, Purohit AP. A Text Book of Pharmacognosy. 8th ed. Pune: Nirali Prakashan; 2008. p. 118.

21] Gairola S, Gupta V, Bansal P, Singh R, Maithani M. Herbal antitussives and expectorants—a review. Int J Pharm Sci Rev Res. 2010;5(2):5–9.

22] Molassiotis A, Bailey C, Caress A, Tan JY. Interventions for cough in cancer. Cochrane Database Syst Rev. 2015;(5):CD007609. doi: 10.1002/14651858.CD007609.pub3.

23] International Conference on Harmonisation (ICH). Stability testing of new drug substances and products. ICH Guideline Q1A(R2). Geneva: ICH; 2003.Deepa P, Kannappan N. Comparative stability study of formulated Ayurvedic health supplement and marketed product. Der Pharmacia Sinica. 2012;3(5):2068–72.

24] Chauhan SK, Agarwal S. Stability studies of herbal drugs. The Eastern Pharmacist. 1999;42(498):35–6.

25] Devkar MJ, Shaikh SMS, Jadhao AG, Sanap J, Patil PA. Formulation and evaluation of herbal syrup. Asian J Pharm Res Dev. 2021 Jun;9(3):16–22. doi:10.22270/ajprd.v9i3.955.

26] Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–8. doi:10.38124/IJISRT20JUN334.

27] Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–8. doi:10.38124/IJISRT20JUN334.

28] Gaikwad DD, Shinde SK, Kawade AV, Jadhav SJ, Gadhave MV. Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests. Pharma Innovation J. 2017;6(2):179–82.

29] Abeshu MA, Geleta B. Medicinal uses of honey. Biol Med (Aligarh). 2016;8(2):279. doi:10.4172/0974-8369.1000279.

30]  Gaikwad DD, Shinde SK, Kawade AV, Jadhav SJ, Gadhave MV. Isolation and standardization of gingerol from ginger rhizome by using TLC, HPLC, and identification tests. Pharma Innovation J. 2017;6(2):179–82.

31] Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–9.

32] Azwanida NN. A review on the extraction methods used in medicinal plants: principle, strength, and limitation. Med Aromat Plants. 2015;4(3):196. doi:10.4172/2167-0412.1000196

33] Patil V, Ahmad S. A practical book of pharmacognosy and phytochemistry. 3rd ed. Pune: Nirali Prakashan; 2022. 102 p. ISBN: 9789388293563.

34]  Kaushik A, Chauhan V, Sudha. Formulation and evaluation of herbal cough syrup. Eur J Pharm Med Res. 2016;3(5):517–22.

35]  Patil JK, Mali DR, More KR, Jain SM. Formulation and evaluation of herbal syrup. World J Pharm Res. 2019;8(6):1061–7. doi:10.20959/wjpr20196-14867.

36] Farhan HM, Egzar K, Sahap EH. Physical and chemical properties of homemade dates syrup (molasses) from middle Iraq cities. Int J Sci Res Publ. 2017 Jan;7(1):1–6.

37] Swain PK, Nayak DP. Design, development & evaluation of a polyherbal syrup from some herbs used as energy booster. Int J Ayurvedic Med. 2013;4(4):374–8. doi:10.47552/ijam.v4i4.354.

38]  Goswami PK, Srivastava RS. Development and evaluation of herbal syrup from root extract of Nothosaerva brachiata and Gomphrena celosioides. Int J Res Pharm Chem. 2016;6(3):473–5.

39] Daware OS, Tijare RD, Chavhan AB. Preparation and evaluation of polyherbal cough syrup: A novel approach. Int J Multidiscip Res. 2023;5(2):1–6

40] Kaushik A, Chauhan V, Sudha. Formulation and evaluation of herbal cough syrup. Eur J Pharm Med Res. 2016;3(5):517–22.

41]  Kumar KPS, Bhowmik D, Tiwari P, Kharel R. Indian traditional herbs Adhatoda vasica and its medicinal applications. J Chem Pharm Res. 2010;2(4):2040–5.

42] Patil AG, Mirajakar KG, Savekar PL, Bugadikattikar CV, Shintre SS. Formulation and evaluation of ginger macerated honey base herbal cough syrup. Int J Innov Sci Res Technol. 2020 Jun;5(6):582–9. doi:10.38124/IJISRT20JUN334.

43] Thakur S, Walia B, Chaudhary G. Formulation and evaluation of Adulsa. Int J Res Publ Rev Res Technol. 1997;4(4):256.

44] Thakur S, Walia B, Chaudhary G. Formulation and evaluation of Adulsa. Int J Res Publ Rev Res Technol. 1997;4(4):256.

45] Mujawar FP, Patil M, Sawale J. Formulation and evaluation of herbal cough syrup of Echinops echinatus Roxb roots. Int J Pharm Technol. 2016 Jun 9;9(6):19222–7.

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