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Author(s): V.Swetha*1, V.Sahithi2, B.Anusha3

Email(s): 1Swethatarunya.11@gmail.com

Address:

    Department of pharmaceutical analysis, School of pharmaceutical sciences and Technoligies JNTUK, Kakinada, India 433003

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4610  

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ABSTRACT:
A common prostaglandin analogue for glaucoma and ocular hypertension patients is Travoprost, which lowers intraocular pressure. The prostaglandin FP receptors, which are found in the ciliary muscle and the trabecular meshwork, are which causes the ocular hypotension, Travoprost is more effective than timolol at lowering intraocular pressure, although there is typically no difference when comparing it to other prostaglandin analog. This article discusses the development and validation of an HPLC method for analyzing a fixed-dose combination of timolol and travoprost, which has demonstrated similar intraocular pressure-lowering effectiveness as when the drugs are used separately. Following ICH Guidelines, the HPLC validation process involves evaluating parameters such as accuracy, specificity, linearity, range, detection and quantification limits, robustness, and system suitability. In the frame of this information, this review aims to provide the compilation and discussion of hplc methods published in the literature for estimation of Travoprost in single or combined dosage form in pharmaceutical dosage forms. the following review discusses the comparative use of hplc by UV/PDA methodologies for Travoprost estimation. The current compilation can be effectively used to enhance Travoprost future analytical research demands.

Cite this article:
V.Swetha, V.Sahithi, B.Anusha. A review on HPLC Methods for Estimation of Travoprost in Combined and Single Pharmaceutical formulation and Bulk. IJRPAS, June 2025; 4 (6): 96-102.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4610


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5.        Wadhwani M, Mishra SK, Angmo D, Velpandian T, Sihota R, Kotnala A, Bhartiya S, Dada T. Evaluation of physical properties of generic and branded Travoprost formulations. Journal of Current Glaucoma Practice. 2016 Aug 5;10(2):49.

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7.        Lim KS, Nau CB, O'Byrne MM, Hodge DO, Toris CB, McLaren JW, Johnson DH. Mechanism of action of Bimatoprost, Latanoprost, and Travoprost in healthy subjects: a crossover study. Ophthalmology. 2008 May 1;115(5):790-5.

8.        Stahl E, Bremond-Gignac D, Landry T, Curtis M, Gedif K, Al Shahwan S, Dixon ER. Pharmacokinetics and safety of travoprost 0.004% ophthalmic solution preserved with polyquad in pediatric patients with glaucoma. Journal of Ocular Pharmacology and Therapeutics. 2017 Jun 1;33(5):361-5.

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11.    Pujari SR, Mahajan SS. DEVELOPMENT OF STABLE FORMULATION OF TRAVOPROST OPHTHALMIC SOLUTION 0.004%.

12.    Kumari VR, Venkateswarrao P, Sunitha A, Keerthy K. Stability indicating RP-HPLC method for simultaneous estimation of travopost and timolol in bulk and pharmaceutical dosage forms. IJPRR. 2015;5(3):176-82.

13.    FEI Luhua, WU Juan , FEI Hanyu. Determination of the Related Substances of Travoprost in Travoprost and Timolol Maleate Eye Drops by HPLC, Herald of Medicine ›› 2023, Vol. 42 ›› Issue (3) : 411-415.

14.    Jothieswari D, Reddy BC, Soniya S, Dharshini Y, Roja K. Method development and validation of simultaneous estimation of timolol maleate and travoprost in bulk and in pharmaceutical dosage form by UV-spectroscopy. J Pharm Bio. 2017;7:22-32.

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