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Author(s): Shaikh Aminoddin Raisoddin1, Shifa Maniya2, Sayeeda Begum3, Naziya Shaikh.4

Email(s): 1aminshaikh82821@gmail.com

Address:

    Bangi College of Pharmacy, Vijayapur 586101 (KA) INDIA

Published In:   Volume - 3,      Issue - 3,     Year - 2024

DOI: Not Available

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ABSTRACT:
Oral drug delivery remains pivotal in pharmaceutical practice due to its convenience, patient compliance, and cost-effectiveness. However, a significant proportion of drugs suffer from poor water solubility, which limits their bioavailability and therapeutic efficacy. This review examines various solubility enhancement strategies aimed at overcoming these challenges in oral drug delivery. Techniques discussed include physical modifications (e.g., particle size reduction, crystal engineering), chemical modifications (e.g., salt formation, pro-drug synthesis), and advanced nanotechnology-based approaches (e.g., Nano sponges, nanocrystals). Solid dispersion technology emerges as a promising strategy to enhance solubility by dispersing drug molecules in inert matrices. The advantages and disadvantages of each technique are critically analysed, emphasizing their applications in improving drug absorption and bioavailability. Challenges such as formulation complexity, stability issues, and regulatory considerations are also discussed. By providing a comprehensive overview, this review aims to guide researchers and pharmaceutical developers in selecting appropriate solubility enhancement strategies to address the persistent challenges of poorly water-soluble drugs in oral drug delivery, thereby improving therapeutic outcomes and patient care.

Cite this article:
Shaikh Aminoddin Raisoddin, Shifa Maniyar, Sayeeda Begum, Naziya Shaikh. Solubility Enhancement of Nevirapine by Solid Dispersion Technique. IJRPAS, May-June 2024; 3(3): 01-09. 2013-2019


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