Author(s):
Fadilullahi Opeyemi Ibiyemi*11, Ismail Kolawole Odetayo22, Fareedah Adeshina33
Email(s):
1ibiyemi.ademola97@gmail.com, 2
Address:
1. Department of Chemistry & Industrial Chemistry, Osun State Water Regulatory Commission, (O.S.W.R.C) Ministry of Water Resources , Osun State, Nigeria
2. Department of Biochemistry & Industrial Chemistry Fountain University, P.M.B. 4491 Osogbo Osun State, Nigeria
3. Department of Biochemistry University of Ilorin, P.M.B 1515, Ilorin, Nigeria
Published In:
Volume - 4,
Issue - 7,
Year - 2025
DOI:
https://doi.org/10.71431/IJRPAS.2025.4707 
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ABSTRACT:
This abstract provides a comprehensive overview of Moringa oleifera, exploring its botanical richness, nutritional abundance, and medicinal potential. Moringa emerges as a botanical marvel deeply entrenched in traditional practices across diverse cultures, owing to its adaptability and significance in various ecological contexts. From its roots to leaves and seeds, every part of the Moringa tree harbors bioactive compounds with diverse pharmacological actions, including anti-inflammatory, antimicrobial, antidiabetic, cardio-protective, and hepatoprotective properties. Its botanical intricacies, nutritional opulence, and phytochemical diversity underscore its transformative potential in botany, nutrition, and medicine. By integrating traditional wisdom with modern scientific inquiry, Moringa illuminates pathways for harnessing its miraculous properties for enhancing human health and well-being, offering promising avenues for future research and therapeutic interventions.
Cite this article:
Fadilullahi Opeyemi Ibiyemi*, Ismail Kolawole Odetayo, Fareedah Adeshina. Miraculous Moringa: A Comprehensive Explanation of its Botanical, Nutritional and Medicinal Potentials. IJRPAS, July 2025; 4 (7): 77-96.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4707
- Abdull Razis AF, Ibrahim MD, Kntayya SB. Health benefits of Moringa
oleifera. Asian Pacific Journal of Cancer Prevention. 2014;15(20):8571-6.
- Adedapo AA, Mogbojuri OM, Emikpe BO. Safety evaluations of the aqueous
extract of the leaves of Moringa oleifera in rats. J Med Plant.
2009;3:586–591.
- Ajibade TO, Arowolo R, Olayemi FO. Phytochemical screening and
toxicity studies on the methanol extract of the seeds of Moringa oleifera.
J Complement Integr Med. 2013;10:11–16.
- Al-Asmari, A.K.; Albalawi, S.M.; Athar, M.T.; Khan, A.Q.;
Al-Shahrani, H.; Islam, M. Moringa oleifera as an anti-cancer agent
against breast and colorectal cancer cell lines. PloS ONE 2015, 10,
e0135814. [Google Scholar] [CrossRef] [PubMed]
- Alhakmani F, Kumar S, Khan SA. Estimation of total phenolic content,
in–vitro antioxidant and anti–inflammatory activity of flowers of Moringa
oleifera. Asian Pac J Trop Biomed. 2013;3:623–627.
- Ambi AA, Abdurahman EM, Katsayal UA, et al. Toxicity evaluation of Moringa
oleifera leaves. Int J Pharmaceut Res Innovat. 2011;4:22–24.
- Anwar F, Latif S, Ashraf M, Gilani AH. Moringa oleifera: a food
plant with multiple medicinal uses. Phytother Res. 2007;21:17–25.
- Araújo LCC, Aguiar JS, Napoleão TH, et al. Evaluation of cytotoxic
and anti-inflammatory activities of extracts and lectins from Moringa
oleifera seeds. PLoS One. 2013;8:e81973.
- Asare GA, Gyan B, Bugyei K, et al. Toxicity potentials of the
nutraceutical Moringa oleifera at supra-supplementation levels. J Ethnopharmacol.
2012;139:265–272.
- Asiedu-Gyekye IJ, Frimpong-Manso S, Awortwe C, et al. Micro- and
macroelemental composition and safety evaluation of the nutraceutical
Moringa oleifera leaves. J Toxicol. 2014. DOI:10.1155/2014/786979.
- Atawodi SE, Atawodi JC, Idakwo GA, et al. Evaluation of the
polyphenol content and antioxidant properties of methanol extracts of the
leaves, stem, and root barks of Moringa oleifera Lam. J Med Food.
2010;13:710–716.
- Awodele O, Oreagbe IA, Odoma S, et al. Toxicological evaluation of
the aqueous leaf extract of Moringa oleifera Lam. (Moringaceae). J
Ethnopharmacol. 2012;139:300–306.
- Bakre AG, Aderibigbe AO, Ademowo OG. Studies on neuropharmacological
profile of ethanol extract of Moringa oleifera leaves in mice. J
Ethnopharmacol. 2013;149:783–789.
- Bennett RN, Mellon FA, Foidl N, et al. Profiling glucosinolates and
phenolics in vegetative and reproductive tissues of the multi-purpose
trees Moringa oleifera L (horseradish tree) and Moringa stenopetala L. J
Agric Food Chem. 2003;51:3546–3553.
- Berkovich, L.; Earon, G.; Ron, I.; Rimmon, A.; Vexler, A.; Lev-Ari,
S. Moringa oleifera aqueous leaf extract down-regulates nuclear
factor-kappaB and increases cytotoxic effect of chemotherapy in pancreatic
cancer cells. BMC Complement. Altern. Med. 2013, 13, 212. [Google Scholar]
[CrossRef] [PubMed]
- Cajuday LA, Pocsidio GL. Effects of Moringa oleifera Lam
(Moringaceae) on the reproduction in male mice (Mus musculus). J Med Plant
Res. 2010;4:1115–1121.
- Cheenpracha S, Park E-J, Yoshida WY, Barit C, Wall M, Pezzuto JM,
Chang LC. Potential anti-inflammatory phenolic glycosides from the
medicinal plant Moringa oleifera fruits. Bioorganic & Medicinal
Chemistry. 2010;18(17):6598–6602. doi:10.1016/j.bmc.2010.03.057
- Chen KH, Chen YJ, Yang CH, et al. Attenuation of the extract from
Moringa oleifera on monocrotaline-induced pulmonary hypertension in rats.
Chin J Physiol. 2012;55:22–30.
- Choudhary MK, Bodakhe SH, Gupta SK. Assessment of the antiulcer
potential of Moringa oleifera root-bark extract in rats. J Acupunct
Meridian Stud. 2013;6:214–220.
- Chuang PH, Lee CW, Chou JY, et al. Anti-fungal activity of crude
extracts and essential oils of Moringa oleifera Lam. Bioresour Technol.
2007;98:232–236.
- Chumark P, Khunawat P, Sanvarinda Y, et al. The in vitro and ex vivo
antioxidant properties, hypolipidemic and antiatherosclerotic activities
of water extract of Moringa oleifera Lam leaves. J Ethnopharmacol.
2008;116:439–446.
- Coppin JP, Xu Y, Chen H, Pan M-H, Ho C-T, Juliani R, Wu Q.
Determination of flavonoids by LC/MS and anti-inflammatory activity in
Moringa oleifera. Journal of Functional Foods. 2013;5(4):1892–1899.
doi:10.1016/j.jff.2013.09.010
- Das N, Sikder K, Ghosh S, et al. Moringa oleifera Lam leaf extract
prevents early liver injury and restores antioxidant status in mice fed
with high-fat diet. Indian J Exp Biol. 2012;50:404–412.
- Debnath S, Biswas D, Ray K, Guha D. Moringa oleifera induced
potentiation of serotonin release by 5-HT(3) receptors in experimental
ulcer model. Phytomedicine. 2011;15:91–95.
- Fahey JW. Moringa oleifera: a review of the medicinal potential.
Acta Horticulturae. 2017;(1158):209–224.
doi:10.17660/actahortic.2017.1158.25
- Faizi S, Siddiqui BS, Saleem R, et al. Hypertensive constituents
from the pods of Moringa oleifera. Planta Med. 1998;64:225–228.
- Fowke, J.H.; Chung, F.L.; Jin, F.; Qi, D.; Cai, Q.; Conaway, C.;
Cheng, J.R.; Shu, X.O.; Gao, Y.T.; Zheng, W. Urinary isothiocyanate
levels, brassica, and human breast cancer. Cancer Res. 2003, 63,
3980–3986.
- Gao, N.; Budhraja, A.; Cheng, S.; Liu, E.H.; Chen, J.; Yang, Z.;
Chen, D.; Zhang, Z.; Shi, X. Phenethyl isothiocyanate exhibits
antileukemic activity in vitro and in vivo by inactivation of Akt and
activation of JNK pathways. Cell Death Dis. 2011, 2, e140.
- Jung, I.L. Soluble extract from Moringa oleifera leaves with a new
anticancer activity. PLoS ONE 2014, 9, e95492.
- Kachik F, Mudlagiri BG, Gary RB, et al. Effects of food preparation
on qualitative and quantitative distribution of major carotenoids
constituents of tomatoes and several green vegetables. J Agric Food
Chem.1992;40(3):390–398.
- Kiranawati TW, Nurjanah N. Improvement of noodles recipe for
increasing breastmilk: design of the Moringa noodles. Am J Food Sci
Technol. 2014;2(3):88–92
- Peñalver R, Martínez-Zamora L, Lorenzo JM, Ros G, Nieto G.
Nutritional and antioxidant properties of Moringa oleifera leaves in
functional foods. Foods. 2022 Apr 12;11(8):1107.
- Priya V, Abiramasundari P, Devi SG, Jeyanthi GP. Antibacterial
activity of the leaves, bark, seed and flesh of Moringa oleifera. International
Journal of Pharmaceutical Sciences and Research. 2011 Aug 1;2(8):2045.
- Sallau B, Mada SB, Ibrahim S. Effect of boiling, simmering and
blanching on the antinutritional content of Moringa oleifera leaves. Int J
Food Nutr Saf. 2012;2:1–6.
- Saleem A, Saleem M, Akhtar MF. Antioxidant, anti-inflammatory and
antiarthritic potential of Moringa oleifera Lam: An ethnomedicinal plant
of Moringaceae family. South African Journal of Botany. 2020 Jan
1;128:246-56.
- Santos AFS, Argolo ACC, Paiva PMG, Coelho LCBB. Antioxidant activity
of Moringa oleifera tissue extracts. Phytotherapy Research.
2012;26(9):1366–1370.
- Sreelatha, S.; Jeyachitra, A.; Padma, P.R. Antiproliferation and
induction of apoptosis by Moringa oleifera leaf extract on human cancer
cells. Food Chem. Toxicol. 2011, 49, 1270–1275.
- Waterman, C.; Cheng, D.M.; Rojas-Silva, P.; Poulev, A.; Dreifus, J.;
Lila, M.A.; Raskin, I. Stable, water extractable isothiocyanates from
Moringa oleifera leaves attenuate inflammation in vitro. Phytochemistry
2014, 103, 114–122.
- Xiao, D.; Srivastava, S.K.; Lew, K.L.; Zeng, Y.; Hershberger, P.;
Johnson, C.S.; Trump, D.L.; Singh, S.V. Allyl isothiocyanate, a
constituent of cruciferous vegetables, inhibits proliferation of human
prostate cancer cells by causing G2/M arrest and inducing apoptosis.
Carcinogenesis 2003, 24, 891–897.
- Yang R, Chang L, Hsu J, et al. Nutritional and functional properties
of moringa leaves from germplasm, to plant, to food, to health. Am Chem
Soc. 2006;1–17.