ABSTRACT:
Objective: Cardioprotective effects of Allium sativum against Doxorubicin induced cardiotoxicity and heart malfunction in the experimental rats. Material and Methods: By examining the enzymatic and non-enzymatic antioxidant positions, serum enzyme levels, and histopathology tissue in albino wistar rats were used to test the protective properties of Ethanolic Extract of Floral Extract of Allium sativum (EEAS) scheduled doxorubicin (DOX). An Ethanolic Extract of Allium sativum (EEAS) administered orally for 14 days (100 mg/kg bw, 200 mg/kg bw, n = 6) was used to induce cardiotoxicity in experimental rats using a large single dosage of doxorubicin (15 mg/body weight). Results: The rats are killed after 14 days of treatment with ketamine and xylazine and biochemical and analyses of the heart tissues were performed. The administration of 100mg/kg, 200 mg/kg of EEAS were significantly decreased the levels of cardiac marker enzymes (p<0.05) and minimized the reduction in heart weight in the DOX-treated group. Superoxide dismutase, glutathione, and catalase levels in heart tissue were much higher than previously, whereas lipid oxide peroxide was significantly lower in the extract (100 & 200 mg/kg bw). Conclusion: Ethanolic Extract of Allium sativum (EEAS) treatment was well controlled against the Doxorubicin induce cardio toxicity and heart malfunction in the experimental rats.