ABSTRACT:
Drugs are delivered to the bloodstream through the skin using self-contained, discrete dose forms called transdermal medications at a controlled rate. It is feasible to improve entrapment efficiency and drug penetration by inserting the drug (Clotrimazole) into Transfersomal gel utilizing the thin film hydration process and two distinct polymers. The study concluded that varying proportions of Span 60 and Tween 80 and soy lecithin are utilized to make transfersomes. The incorporation of transfersomal dispersion into gelling agents. The Drug and excipient study performed by FTIR revealed that they are compatible with each other. Due to the highest entrapment efficiency, which was estimated to be 91.91%, out of all the batches, F1 proved to be an optimized batch. Zeta potential and PDI was -25.8 mV and 62.87 nm respectively. Carbopol 934 and Xanthan Gum Gelling agent were used to prepare Transfersomal Gel. Then it was compared using evaluation criteria such as drug content, spreadability, extrudability, and in vitro drug release using a Franz diffusion cell. Optimized 1% Carbopol 934 Gel then compared with Marketed Canesten cream for Antifungal study. Our research discovered that the Transfersomal formulation provided a prolonged and sustained medication delivery with improved patient compliance and increased bioavailability. Transdermal use of the transfersomal formulation might be the most effective.
Cite this article:
Pallavi Chavan, Kedar Bavaskar, Rutuja Sawant , Dr. Ashish Jain.Preparation and Optimization of Clotrimazole Transdermal Gel of Nanosize Transfersome with Different Non-Ionic Surfactant. IJRPAS, 2024; 3(1): 123-140.
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