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Author(s): J.J. Naik1

Email(s): 1naikjayu91@gmail.com

Address:

    JES’s College of Pharmacy, Nandurbar, Dist Nandurbar, MS, India.

Published In:   Volume - 3,      Issue - 2,     Year - 2024

DOI: Not Available

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ABSTRACT:
The aim of this study was to prepare and evaluate Ritonavir for enhancing the dissolution rate and Bioavailability several methods and newer emerging technologies have been developed. For the solubility enhancement of ritonavir solid dispersion, complexation, particle size reduction method was used. Solubility enhancement method which showing the best result after evaluation of parameter was selected for preparation of immediate release tablet of ritonavir by using appropriate excipients. Particle size reduction method was selected for the formulation of tablets. The physical state of the ritonavir drug and excipients was characterized by differential scanning calorimetry, powder X-ray diffraction, and U.V spectroscopy. Ritonavir drug were formulated into tablet by direct compression method. On comparing with pure drug and formulated tablet, the dissolution of Ritonavir was enhanced dramatically. Formulation showed faster drug release. The experiment was conclusively indicated that the use of particle size reduction method by using water soluble carriers improved the solubility of Ritonavir.

Cite this article:
J.J. Naik. Solubility enhancement and tablet formulation of Ritonavir


1.      Löbenberg, R. and Amidon, G.L., 2000. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. European journal of pharmaceutics and biopharmaceutics50(1), pp.3-12.

2.      Savjani, K.T., Gajjar, A.K. and Savjani, J.K., 2012. Drug solubility: importance and enhancement techniques. International Scholarly Research Notices2012.

3.      Mahapatra, A.P., Patil, V. and Patil, R., 2020. Solubility enhancement of poorly soluble drugs by using novel techniques: A comprehensive review. Int J Pharm Tech Res13(2), pp.80-93.

4.      Kumar, P. and Singh, C., 2013. A study on solubility enhancement methods for poorly water soluble drugs. American Journal of Pharmacological Sciences1(4), pp.67-73.

5.      Das, S.K., Roy, S., Kalimuthu, Y., Khanam, J. and Nanda, A., 2012. Solid dispersions: an approach to enhance the bioavailability of poorly water-soluble drugs. International journal of pharmacology and pharmaceutical technology1(1), pp.37-46.

6.      Saran, K., Srujan Kumar, M. and Subrahmanyam, K.V., 2013. Enhancement of solubility of Ritonavir by using Solid dispersion Technique. International Journal of innovative Pharmaceutical Sciences and Research1(2), pp.266-280.

7.      Sinha, S., Ali, M., Baboota, S., Ahuja, A., Kumar, A. and Ali, J., 2010. Solid dispersion as an approach for bioavailability enhancement of poorly water-soluble drug ritonavir. Aaps Pharmscitech11, pp.518-527.

8.      Wairkar, S.M. and Gaud, R.S., 2013. Solid dispersions: Solubility enhancement technique for poorly soluble drugs. International Journal of Research in Pharmaceutical and Biomedical Sciences4(3), p.847.

9.      Singh, J., Walia, M. and Harikumar, S.L., 2013. Solubility enhancement by solid dispersion method: a review. Journal of drug delivery and Therapeutics3(5), pp.148-155.

10.  Jagtap, S., Magdum, C., Jadge, D. and Jagtap, R., 2018. Solubility enhancement technique: a review. Journal of pharmaceutical sciences and Research10(9), pp.2205-2211.

11.  Gupta, S.K., Gupta, R.K., Pandey, N.K., Singh, S.K. and Kumar, B., 2018. Solubility enhancement techniques: A comparative study. Int J Res Anal Rev5, p.73.

12.  Vemula, V.R., Lagishetty, V. and Lingala, S., 2010. Solubility enhancement techniques. International journal of pharmaceutical sciences review and research5(1), pp.41-51.

13.  Kumar, S. and Singh, P., 2016. Various techniques for solubility enhancement: An overview. The Pharma Innovation5(1, Part A), p.23.

14.  Neha, S. and Meenakshi, B., 2011. Solubility enhancement technique: A review. Int J Pharm Erud1, pp.40-53.

15.  Jaya, S., Chowdary, K.P.R. and Rajeswara, R.P., 2013. Enhancement of dissolution rate and formulation development of ritonavir tablets by solid dispersion technologies. Int J Pharma Therape4, pp.51-8.

16.  Bonthagarala, B., Dasari, V. and Kotra, V., 2019. Solubility enhancement effect at absorption site on bioavailability of ritonavir using liquisolid technique. Therapeutic delivery10(5), pp.295-310.

17.  Bhalani, D.V., Nutan, B., Kumar, A. and Singh Chandel, A.K., 2022. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines 2022, 10, 2055.

18.  Mamatha, T., Taha Minhaj, F. and Anitha, N., 2016. Solid Dispersion as an Approach for Dissolution Enhancement of Poorly Water Soluble Drug Ritonavir. Int J Pharm Tech Res9(8), pp.154-165.

19.  Khadka, P., Ro, J., Kim, H., Kim, I., Kim, J.T., Kim, H., Cho, J.M., Yun, G. and Lee, J., 2014. Pharmaceutical particle technologies: An approach to improve drug solubility, dissolution and bioavailability. Asian journal of pharmaceutical sciences9(6), pp.304-316.

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