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Author(s): J.J. Naik1

Email(s): 1naikjayu91@gmail.com

Address:

    JES’s College of Pharmacy, Nandurbar, Dist Nandurbar, MS, India.

Published In:   Volume - 3,      Issue - 2,     Year - 2024

DOI: Not Available

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ABSTRACT:
The aim of this study was to prepare and evaluate Ritonavir for enhancing the dissolution rate and Bioavailability several methods and newer emerging technologies have been developed. For the solubility enhancement of ritonavir solid dispersion, complexation, particle size reduction method was used. Solubility enhancement method which showing the best result after evaluation of parameter was selected for preparation of immediate release tablet of ritonavir by using appropriate excipients. Particle size reduction method was selected for the formulation of tablets. The physical state of the ritonavir drug and excipients was characterized by differential scanning calorimetry, powder X-ray diffraction, and U.V spectroscopy. Ritonavir drug were formulated into tablet by direct compression method. On comparing with pure drug and formulated tablet, the dissolution of Ritonavir was enhanced dramatically. Formulation showed faster drug release. The experiment was conclusively indicated that the use of particle size reduction method by using water soluble carriers improved the solubility of Ritonavir.

Cite this article:
J.J. Naik. Solubility enhancement and tablet formulation of Ritonavir


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