International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2'-hydroxychalcone

Author(s): Adebayo T. Bale*1, Wahab A. Osunniran2, Mohammed H. Sadiya3, Fausat O. Adebona4

Email(s): 1adebayo.bale@kwasu.edu.ng

Address:

    Kwara State University, Nigeria

Published In:   Volume - 4,      Issue - 4,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4412  

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ABSTRACT:
Chalcones are aromatic ketones that form a key structural unit in various bioactive compounds and possess a variety of biological properties. Chalcone is a member of flavonoid family and are either natural or synthetic products. The study focuses on the synthesis of 2-methoxy-2-hydroxychalcone and its transition metal complexes. The ligand was obtained from the reaction between 2-hydroxyacetophenone and 2-methoxybenzaldehyde with NaOH as a catalyst through mechanochemical grinding method at room temperature resulting in a pale yellow-coloured product. The metal complexes were synthesized by reacting the ligand with metal(II) chlorides in ratios 2:1. The resulting Co(II), Cu(II)and Mn(II), Cu(II) complexes were dark brown, light green and orange-red in colour respectively. The chalcone ligand and the metal complexes were characterized using different analytical techniques such as melting point, solubility test, Fourier Transform Infrared (FT-IR) and Ultraviolet-Visible (UV-Vis) spectroscopy. The chalcone melted at 117 ºC while the Co(II), Cu(II) and Mn(II) complexes melted at 230 ºC, 244 ºC and 258 ºC respectively indicating thermal stability. The chalcone and their metal complexes were found to be soluble in polar solvents. The FT-IR spectra showed absorption bands at 1604-1638 cm-1 and 1527-1605 cm-1 indicating the presence of carbonyl (C=O) and C=C respectively. The spectra of the metal complexes showed M-O absorption bands in between 467-574 cm-1. The chalcone and its metal complexes were obtained via mechanochemistry. The method gave high yield of products in a short reaction time.

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Cite this article:
Adebayo T. Bale, Wahab A. Osunniran, Mohammed H. Sadiya, Faosat O. Adebona. FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2'-hydroxychalcone. IJRPAS, April 2025; 4 (4): 113-123DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4412


Rojas, J., Domı́nguez, J. N., Charris, J. E., Lobo, G., Payá, M., & Ferrándiz, M. L. (2002). Synthesis and inhibitory activity of dimethylamino-chalcone derivatives on the induction of nitric oxide synthase. European Journal of Medicinal Chemistry, 37(8), 699-705.

2.      Tomar, V., Bhattacharjee, G., Kamaluddin, G.R., Srivastava, K., Puri., S.K. (2010) Synthesis of new chalcone derivatives containing acridinyl moiety with potential anti- malarial activity, European Journal of Medicinal Chemistry. 45, 745–751.

3.      Real, G. (1967). The action of chalcones and their derivatives on biological systems. Journal of Biological Chemistry, 242(9), 1912-1915. https://doi.org/10.1016/S0021-9258(18)96021-4

4.      Takahashi, H., Yamashita, H., & Yamaguchi, T. (1998). Anti-inflammatory and analgesic activity of some chalcones in experimental animals. Biological & Pharmaceutical Bulletin, 21(5), 462–466. https://doi.org/10.1248/bpb.21.462

5.      Aksoz, E., Oren, I, Akar, Z., & Kilic, T. (2011). Novel approaches for the detection of bioactivity of chalcones: A review. Chemistry & Biodiversity, 8(6), 1106–1115.

6.      Gomes, M. N., Muratov, E. N., Pereira, M., Peixoto, J. C., Rosseto, L. P., Cravo, P. V., Andrade, C.H. and Neves, B. J. (2017). Chalcone Derivatives: Promising Starting Points for Drug Design. Molecules, 22(8), 1-25. doi:10.3390/molecules22081210

7.      Rateb, N. M., & Zohdi, H. F. (2009). Atom-efficient, solvent-free, green synthesis of chalcones by grinding. Synthetic Communications®, 39(15), 2789-2794. 

8.      Tabti, S., Djedouani, A., Aggoun, D., Warad, I., Rahmouni, S., Romdhane, S. and Fouzi, H. (2018). New Cu(II), Co(II) and Ni(II) Complexes of Chalcone Derivatives: Synthesis, X-ray Crystal Structure, Electrochemical Properties and DFT Computational Studies. Journal of Molecular Structure. 1155, 11-20. doi:10.1016/j.molstruc.2017.10.084

9.      Bale, A. T., Fasina, T. M., & Shaibu, R. O. (2022). Synthesis and biological study of substituted 2”-Hydoxy, 2”, 4”-dichloro chalcones and their Co(II), Cu(II) and Ni(II) complexes for their antioxidant and antimicrobial potentials. Advanced Journal of Chemistry-Section A, 5, 94-103

10.  Devi, J.M., Tharmaraj, P., Ramakrishnan, S.K., & Ramachandran, K. (2008). On the thermal properties of metal (II) complexes of chalcone. Materials Letters, 62, 85

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