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Author(s): J.S. Rudra Bhavani1, Farath Sulthana2, Kalva Swapna3, Tadikonda Rama Rao4, Mugdivari Sangeetha*5

Email(s): 1sangeetha.kodiganti@gmail.com

Address:

    CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana,India-501401

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4603  

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ABSTRACT:
This study presents the synthesis and biological evaluation of oxazine and thiazine derivatives derived from chalcone as potential agents against microbial pathogens. The derivatives were synthesized by using reported methodology from chalcone. Chalcones, characterized by their α, β-unsaturated carbonyl system, exhibit various pharmacological activities such as anti-inflammatory, antioxidant, antimicrobial, anticancer, and antiviral effects. The chemical structures of the synthesized compounds were confirmed using spectroscopic techniques including FTIR. The antimicrobial activity of the synthesized oxazine and thiazine derivatives was evaluated against a panel of clinically relevant microorganisms, encompassing Bacillus subtilis and Escherichia coli. Preliminary results demonstrate that certain oxazine and thiazine derivatives exhibit significant antimicrobial activity, with some compounds displaying potent inhibition against a broad spectrum of microbial species. These findings suggest that oxazine and thiazine derivatives derived from chalcone hold promise as novel antimicrobial agents. Further optimization and preclinical investigations are warranted to fully explore their potential for clinical applications in combating microbial infections.

Cite this article:
J.S. Rudra Bhavani, Farath Sulthana, Kalva Swapna, Tadikonda Rama Rao, Mugdivari Sangeetha. Synthesis and Biological Evaluation of Oxazine and Thiazine derivatives as Potent microbial agents. IJRPAS, June 2025; 4 (6): 24-35.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4603


1.      Salehi B, Quispe C, Chamkhi I, El Omari N, Balahbib A, Sharifi-Rad J, et al. Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence. Front Pharmacol. 2021 Jan 18; 11:592654. 

2.      Bentrad N, Hamida-Ferhat A. Analytical approaches used in the profiling of natural products with a therapeutic target: a global perspective on nutrition and health. Studies in Natural Products Chemistry. 2022 Jan 1; 72:57–101. 

3.      Zhuang C, Zhang W, Sheng C, Zhang W, Xing C, Miao Z. Chalcone: A Privileged Structure in Medicinal Chemistry. Chem Rev [Internet]. 2017 Jun 6 [cited 2024 Feb 12];117(12):7762.

4.      Rammohan A, Reddy JS, Sravya G, Rao CN, Zyryanov G V. Chalcone synthesis, properties and medicinal applications: a review. Environmental Chemistry Letters 2020 18:2 [Internet]. 2020 Jan 6 [cited 2024 Feb 11];18(2):433–58. 

5.      Elkanzi NAA, Hrichi H, Alolayan RA, Derafa W, Zahou FM, Bakr RB. Synthesis of Chalcones Derivatives and Their Biological Activities: A Review. ACS Omega [Internet]. 2022 Aug 16 [cited 2024 Feb 12];7(32):27769–86. 

6.      Ouyang Y, Li J, Chen X, Fu X, Sun S, Wu Q. Chalcone Derivatives: Role in Anticancer Therapy. Biomolecules [Internet]. 2021 Jun 1 [cited 2024 Feb 12];11(6). 

7.      Maniewska J, Wiatrak B, Czyżnikowska Ż, Szczęśniak-Sięga BM. Synthesis of new tricyclic 1,2-thiazine derivatives with anti-inflammatory activity. Int J Mol Sci [Internet]. 2021 Aug 1 [cited 2024 Feb 12];22(15):7818. 

8.      Domínguez JN, León C, Rodrigues J, De Domínguez NG, Gut J, Rosenthal PJ. Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem [Internet]. 2005 May 19 [cited 2024 Feb 12];48(10):3654–8. 

9.      Fu Y, Liu D, Zeng H, Ren X, Song B, Hu D, et al. New chalcone derivatives: synthesis, antiviral activity and mechanism of action. RSC Adv [Internet]. 2020 Jun 26 [cited 2024 Feb 12];10(41):24483–90. 

10.  Hsieh CT, Hsieh TJ, El-Shazly M, Chuang DW, Tsai YH, Yen CT, et al. Synthesis of chalcone derivatives as potential anti-diabetic agents. 2012 [cited 2024 Feb 12].

11.  Rammohan A, Reddy JS, Sravya G, Rao CN, Zyryanov GV. Chalcone synthesis, properties and medicinal applications: a review. Environ Chem Lett. 2020;18(3):985-1000 doi:10.1007/s10311-019-00959-w

12.  Xu M, Wu P, Shen F, Ji J, Rakesh KP. Chalcone derivatives and their antibacterial activities: current       development. BioorgChem. 2019;103133. doi:10.1016/j.bioorg.2019.103133.

13.  Anto RJ, Sukumaran K, Kuttan G, Rao MNA, Subbaraju V, Kuttan R. Anticancer and antioxidant activity of synthetic chalcones and related compounds. Cancer Lett. 1995 Oct 20;97(1):33-7.

14.  Leite FF, de Sousa NF, de Oliveira BHM, Duarte GD, Ferreira MDL, Scotti MT, Filho JMB, Rodrigues LC, de Moura RO, Mendonça-Junior FJB, et al. Anticancer Activity of Chalcones and Its Derivatives: Review and In Silico Studies. Molecules. 2023;28(10):4009.

15.  Nowakowska Z. A review of anti-infective and anti-inflammatory chalcones. Eur J Med

Chem. 2007 Feb;42(2):125-37.

16.  Morsy NM, Hassan AS. Synthesis, reactions, and applications of chalcones: A review. Eur. J. Chem. [Internet]. 2022 Jun. 30 [cited 2024 May 4];13(2):241-52. 

17.  Mezgebe K, Melaku Y, Mulugeta E. Synthesis and Pharmacological Activities of Chalcone and Its Derivatives Bearing N-Heterocyclic Scaffolds: A Review. ACS Omega.

2023;8(22):19194–19211. DOI: 10.1021/acsomega.3c01035.

18.  Okolo EN, Ugwu DI, Ezema BE, et al. New chalcone derivatives as potential antimicrobial and antioxidant agent. Sci Rep. 2021;11:21781. DOI: 10.1038/s41598-02101292-5.

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