ABSTRACT:
Diabetes mellitus is a complicated metabolic disease, particularly type II. This is linked to elevated blood glucose levels. because of β cell malfunction, insulin resistance, and imbalance. Because of its ability to manage insulin, body weight, and glycemia, metformin HCL is used extensively. The purpose of this study was to use Neem gum and fenugreek gum polymer to create, develop, and assess a floating medication delivery system for metformin hydrochloride for the diabetes condition. Traditional oral antidiabetic medications frequently experience restrictions like low bioavailability, brief half-life, and regular dosing necessities. Gastroretentive drug delivery systems (GRDDS) provide a method to improve gastric retention, resulting in extended drug release and enhanced treatment effectiveness. The current research centers on the creation and advancement of a floating tablet of Metformin with sustained-release properties. Metformin Hydrochloride (MH) focused on increasing bioavailability and boosting patient compliance. Different formulations were created using hydrophilic matrix-forming polymers such neem gum, fenugreek gum and citric acid in addition to sodium bicarbonate as an effervescent agent. The tablets were assessed for both pre-compression and post-compression characteristics, such as bulk density, compressibility index, swelling capacity, friability, floating lag time, and drug release kinetics.