Abstract View

Author(s): M Sohil M Shabbir*1, Shaikh Imran Kalam2, Dr. G.J. Khan3, Shaikh Md Moiz4, Shaikh Aman5

Email(s): 1mohammadsohil8668@gmail.com

Address:

    JIIU’s Ali Allana College of Pharmacy Akkalkuwa, Dist-Nandurbar -425415, Maharashtra, India

Published In:   Volume - 4,      Issue - 1,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4101  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
Paul Ehrlich's idea of a "magic bullet" has evolved into Nano medicine. In order to circumvent the particular harmful effect of traditional drug distribution, targeted drug delivery reduces the amount of drug needed for therapeutic efficacy by delivering the drug moiety directly to the specified body location (organ, cellular, and subcellular level of specific tissue). The idea of a "magic bullet" was developed to achieve this aim, and after more than a century of research, scientists created a number of devices that are nanometers in size, which is known as "Nano medicine." Among the carrier systems being studied include polymers, cellular/subcellular systems, and colloidal (vesicular and multi particulate) carriers. The necessity and advantages of targeting, along with its basic ideas, techniques, and carrier systems, are covered in this article.

Cite this article:
M Sohil M Shabbir, Shaikh Imran Kalam, Dr. G.J. Khan, Shaikh Md Moiz, Shaikh Aman. Targeted Drug Delivery System. IJRPAS, Jan 2025; 4(1): 1-19DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4101


1.                  Harendra, S., & VipulanandanC. (2006). Production and Characterization of Liposome Systems for Pharmaceutical Applications, Vipulanandan Center for Innovative Grouting Material and Technology (CIGMAT), Department of Civil and Environmental Engineering University of Houston: Houston, pp. 77202–4003

2.                  Marchianoa, V., Matosb, M., Pertierraa, E. S., Gutiérrezb, G., & Blanco-Lópeza, M. C. (2020). Vesicles as antibiotic carrier: State of art. International Journal of Pharmaceutics, 585, 119478.

3.                  Cha, Y., Son, B., & Ryu, S. (2019). Effective removal of staphylococcal biofilms on various food contact surfaces by Staphylococcus aureus phage endolysin LysCSA13. Food Microbiology, 84, 103245.

4.                  Chunyan, L., Zhang, L., Zhu, W., Guo, R., Sun, H., Chen, X., & Deng, N. (2020). Barriers and strategies of Cationic Liposomes for Cancer Gene Therapy. Molecular Therapy-Methods & Clinical Development, 18, 751–764.

5.                  Rodrigues, B. S., Kanekiyo, T., & Singh, J. (2020). In vitro and in vivo characterization of CPP and transferrin modified liposomes encapsulating pDNA. Nano medicine: Nanotechnology, Biology and Medicine, 28, 102225.

6.                  Bezerra, C. F., Alencar Junior, J. G., Honorato, R. L., & Santos, A. T. L. (2020). Antifungal activity of furnesol incorporated in liposomes and associated with fluconazole. Chemistry and Physics of Lipids, 233, 104987.

7.                  Oliveira, J. K., Nakamura, T. U., Correa, A. G., Petrilli, R., Vianna Lopez, R. F., Nakamura, C. V., & Velty, R. A. (2020). Liposome-based nanocarrier loaded with a new quinoxaline derivative for the treatment of cutaneous leishmaniasis. Materials Science and Engineeting: C, 110, 110720.

8.                  Zhang, Y., Wei, H., Du, Y., Ying, D., Zhao, C., Zhang, Y., Zhang, H., Yin, L., & Xinsong, L. (2020). Dimeric artesunate phospholipid-conjugated liposomes as promising anti-inflammatory therapy for rheumatoid arthritis. International Journal of Pharmaceutics, 576, 119178.

9.                  Zhang, Z. J., & Michniak-Kohn, B. (2020). Flavosomes, novel deformable liposomes for the co- delivery of anti-inflammatory compounds to skin. International Journal of Pharmaceutics, 585, 119500.

10.              Bai, L., Fei, W. D., Ying, Y. G., Miao, H., Du, F., Zhang, W. Y., Yang, L. L., & Liu, Y. J. (2020). Liposomes encapsulated iridium (III) polypyridyl complexes enhance anticancer activity in vitro and in vivo. Journal of Inorganic Biochemistry, 205, 111014.

11.              Li, Y., Tan, X., Liu, X., Liu, L., Fang, Y., Rao, R., Yuanyuan, R., Yang, X., & Liu, W. (2020). Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance. Asian Journal of Pharmaceutical Sciences, 15(5), 646–660.

12.              Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipids. Journal of Molecular Biology, 13(1), 238–252.

13.              Morgan, J. R., Williams, L. A., & Haward, C. B. (1985). Technetium-labelled liposome imaging for deep-seated infection. British Journal of Radiology, 58, 35–39.

14.              Aghdam, M. A., Bagheri, R., Mosafer, J., Baradaran, B., Hashemzaei, M., Baghbanzadeh, A., de la Guardia, M., & Mokhtarzadeh, A. (2019). Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release. Journal of Controlled Release, 315, 1–22.

15.              Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, S. Y., Samiei, M., Kouhi, M., & Nejati-Koshki, K. (2013). Liposome: Classification, preparation, and applications. Nanoscale Research Letters. 8(1), 102.

16.              Torchilin, V. P. (2005). Recent advances with liposomes as pharmaceutical carriers. Nature Reviews Drug Discovery, 4(2), 145–160.

17.              Kim, E.-M., & Jeong, H. (2021). Liposomes: Biomedical Applications. Chonnam Medical Journal, 57(1), 27–35

18.              Guimarães, D., Cavaco-Paulo, A., & Nogueira, E. (2021). Design of liposomes as drug delivery system for therapeutic applications. International Journal of Pharmaceutics. 601, 120571.

19.              Shah, S., Dhawan, V., Holm, R., Nagarsenker, M. S., & Perrie, Y. (2020). Liposomes: Advancements and innovation in the manufacturing process. Advanced Drug Delivery Reviews., 2020(154–155), 102–122.

20.              Woodle, M. C. (1995). Sterically stabilized liposome therapeutics. Advanced Drug Delivery Reviews, 16(2–3), 249–265.

21.              Paltauf, F., & Hermetter, A. (1990). Phospholipids  Natural, Semisynthetic, Synthetic. In I. Hanin & G. Pepeu (Eds.), Phospholipids: Biochemical, Pharmaceutical, and Analytical onsiderations (pp. 1–12). Springer.

22.              Nagayasu, A., Uchiyama, K., & Kiwada, H. (1999). The size of liposomes: A factor which effects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs. Advanced Drug Delivery Reviews. 40, 75–87.

23.              Li, J., Wang, X., Zhang, T., Wang, C., Huang, Z., Luo, X., & Deng, Y. (2015). A review on phospholipids and their main applications in drug delivery systems. Asian Journal of Pharmaceutical Sciences, 10(2), 81–98.

24.              Gensure, H., Rebekah, M. L., Zeidel, & Hill, W. G. (2006). Lipid raft components cholesterol and sphingomyelin increase H +/OH- permeability of phosphatidylcholine membranes. Biochemical Journal, 398(3), 485–495.

25.              Spec, I. S. S., Waterhouse, D. N., Madden, T. D., Cullis, P. R., Bally, M. B., Mayer, L. D., & Webb, M. S. (2005). In: Liposomes (pp. 40–57). Methods in Enzymology, Elsevier Academic Press.

26.              Mozafari, M Reza. (2007). Nanomaterials and Nano systems for Biomedical Applications (pp. 83– 98). Springer.

27.              Sackmann, E. (1994). Membrane bending energy concept of vesicle-and cell-shapes and shape- transitions. FEBS Letters, 346(1), 3–16.

28.              Suntres, Z. E. (2011). Liposomal Antioxidants for Protection against Oxidant-Induced Damage. Journal of Toxicology, 1–16.

29.              Maruyama, K., Ishida, O., Kasaoka, S., Takizawa, T., Utoguchi, N., & Shinohara, A. (2004). Intracellular targeting of sodium mercaptoundecahydrododecaborate (BSH) to solid tumors by transferrin-PEG liposomes, for boron neutron-capture therapy (BNCT). Journal of Controlled Release, 98(2), 195–207.

30.              Lamichhane, N., Udayakumar, T. S., D’Souza, W. D., Simone, C. B., Raghavan, S. R., Polf, J., & Mahmood, J. (2018). Liposomes: Clinical Applications and Potential for image-Guided Drug Delivery. Molecules, 23(2), 288.

31.              Cagdas, M., Sezer, A. D., & Bucak, S. (2014). Liposomes as potential drug carrier systems for drug delivery, application of nanotechnology in drug delivery. Ali Demir Sezer, IntechOpen.

32.              Knop, R., & Hoogenboom, D. (2010). U.S. Schubert Fischer Poly. (Ethylene glycol) in drug delivery: pros and cons as well as potential alternatives. Angewandte Chemie International Edition, 49(36), 6288–6388.

33.              Taira, M. C., Chairamoni, N. S., Pecuch, K. M., & Alonso-Romanowski, S. (2004). Stability of liposomal formulations in physiological conditions for oral drug delivery. Drug Delivery, 11, 123– 128.

34.              Sagahara, S., Kajiki, M., Kuriyama, H., & Kobayashi, T. (2006). Complete regression of Xenog rafted human carcinomas by a paclitaxel-carboxymethyl dextran conjugate (AZ10992). Journal Controlled Release, 117, 40–50.

35.              Mozafari, M. R., & Mortazavi, M. S. (2005). Nano liposomes: From Fundamentals to Recent Developments. Trafford Publishing Co Ltd.

36.              Lasic, D. D. (1993). Kinetic and thermodynamic effects in the formulation of amphiphilic colloidal particles. Journal of Liposome Research. 3(2), 257–273.

37.              Gref, R., Minamitake, Y., Peracchia, M. Y., Trubetskoy, V., Torchilin, V., & Langer, R. (1994). Biodegradable long-circulating polymeric nanospheres. Science, 18, 1600–1603.

38.              Metselaar, J. M., Bruin, P., De Boer, L. W., De Vringer, T., Snel, C., Oussoren, C., Wauben, M. H., Crommelin, D. J., Storm, G., & Hennink, W. E. (2003). A novel family of L-amino acid-based biodegradable polymer-lipid conjugates for the development of long-circulating liposomes with effective drug-targeting capacity. Bioconjugate Chemistry, 14(6), 1156–1164.

39.              Krieg, A. M. (2001). From bugs to drugs: Therapeutic immunomodulation with oligodeoxynucleotides containing CpG sequences from bacterial DNA. Antisense Nucleic Acid Drug Development, 11(3), 181–188.

40.              Mozafari, M. R., Flanagan, J., Matia-Merino, L., Awati, A., Omri, A., Suntres, Z. E., & Singh, H. (2006). Recent trends in the lipid-based Nano encapsulation of antioxidants and their role in foods. Journal of the Science of Food and Agriculture. 86(13), 2038–2045.

41.              Garti, N. (2008). Delivery and controlled release of bioactives in foods and nutraceuticals. Woodhead Publishing Limited.

42.              Zarif, L., Graybill, J. R., Perlin, D., & Mannino, R. J. (2000). Cochleates: New lipid based drug delivery system. Journal of Liposome Research, 10(4), 523–538.

43.              Zarif, L. (2002). Elongated supramolecular assemblies in drug delivery. Journal Controlled Release. 81(1–2), 7–23.

44.              Tardi, C., Drechsler, M., Bauer, K. H., & Brandl, M. (2001). Steam sterilisation of vesicular phospholipid gels. International Journal of Pharmaceutics, 217(1–2), 161–172.

45.              Rafe, M. R., & Ahmed, Z. (2017). Liposomal drug delivery systems have opened a new window in pharmaceutical sciences: A literature-based review. Asian Journal of Pharmaceutics, 11(4), 250– 254.

46.              Bulbake, U. Doppalapudi, S. Kommineni, N. Khan, W. Liposomal Formulations in Clinical Use: An Updated Review. Pharmaceutics, 2017; 9.

47.              Bangham, A. D., Standish, M. M., & Weissmann, G. (1965). The action of steroids and streptolysin S on the permeability of phospholipid structures to cations. Journal of Molecular Biology, 13(1), 253–259.

48.              Zhang, H. (2017). Thin film hydration followed by Extrusion Method for Liposome Preparation. Methods in Molecular Biology, 1522, 17–22.

49.              Sharma, N., & Verma, S. (2017). Current and future prospective of liposomes as drug delivery vehicles for the effective treatment of cancer. International journal of Green Pharmacy, 11(3), 8377.

50.              Batzri, S., & Korn, E. D. (1973). Single bilayer liposomes prepared without sonication. Biochimica ET Biophysica Acta (BBA)  Biomembranes, 298(4), 1015–1019.

51.              Deamer, D. W. (1978). Preparation and properties of ether injection liposomes. Annals of the New York Academy of Sciences, 308, 250–258.

 

Related Images:



Recent Images



A Review on Diabetes Mellitus: Type1 & Type2
Formulation and Evaluation of Herbal Hair Mask
FT-IR and UV-Vis Spectroscopic studies of Cd(II), Hg(II) and Zn(II)  metal complexes of 2-methoxy-2
FT-IR and UV-Vis Spectroscopic studies of Co(II), Cu(II) and Mn(II) metal complexes of 2-methoxy-2
Simultaneous UV Spectrophotometric Analysis of Paracetamol and Ibuprofen in an Ethanol–NaoH Solvent System
A Review on Antiseptic Gargle
Formulation and Characterisation of Papaya Leaf Gel
Formulation and Characterisation of Herbal Neem Soap
Formulation and Evaluation of Herbal Hair Serum
Pharmaceutical Marketing Role to Adapt Drug Promotional Practices at the duration times  of Pandemic Covid-19

Tags


Recomonded Articles:

Author(s): Mansoori Safwan Salim; Prof. Rehan Deshmuhk; Dr. G.J. Khan; Shaikh Amaan; Sayyed Ahamad Sayyed Kaleem; Hamza Iliyas Amliwala

DOI:         Access: Open Access Read More

Author(s): Baburao Mohite; Manisha Mane; Sarika Suryavanshi; Shrirang Kharmate; Pranali Patil; Anand Gadad.

DOI:         Access: Open Access Read More

Author(s): Museb shaikh Mukhtar; Khalifa Mahmadasif Y; Pathan Ayyaj Magbul; Shaikh Faisal; Shaikh Aman; MD Moiz, Shaikh Arbaj.

DOI:         Access: Open Access Read More

Author(s): Pratiksha S. Behare*, Sakshi V. Patil, Dipali S. Chaudhari, Devesh P. Bhavsar Akanksha B. Pardhi

DOI:         Access: Open Access Read More

Author(s): M Sohil M Shabbir*, Shaikh Imran Kalam, Dr. G.J. Khan, Shaikh Md Moiz, Shaikh Aman

DOI: https://doi.org/10.71431/IJRPAS.2025.4101         Access: Open Access Read More

Author(s): Aman Shaikh; Dr. GJ khan; Imran Kalam; Shaikh Md. Moiz; M Sohil M Shabbir

DOI:         Access: Open Access Read More

Author(s): Pradnya P. Patil; Ankita S. Bhadane; Devesh P. Bhavsar

DOI:         Access: Open Access Read More

Author(s): M Sohil M Shabbir; Shaikh Imran Kalam; Aejaz Ahmad; G.J. Khan; Md Moiz; Aman Shaikh

DOI:         Access: Open Access Read More

Author(s): Shaikh Md Moiz; Shaikh Imran Kalam; Dr.G.J.Khan; Aman Shaikh; M Sohil M Shabbir

DOI:         Access: Open Access Read More

Author(s): Soham Mandal; Moumita karmakar

DOI:         Access: Open Access Read More

Author(s): Soham Mandal*, Moumita karmakar

DOI:         Access: Open Access Read More