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Author(s): Mr. Tanish V. Jain*1, Mr. Kunal M. Jain2, Dr.Rahul B. Lovhare3, 4, Dr.S.P.Pawar5

Email(s): 1tanjain2345@gmail.com, 2

Address:

    P.S.G.V.P. Mandal’s College of Pharmacy, Shahada, Maharashtra, India.

Published In:   Volume - 4,      Issue - 4,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4408  

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ABSTRACT:
Ibrutinib, a recently approved medicine by the FDA, treats lymphoid malignancies such as mantle cell lymphoma and chronic lymphocytic leukaemia. It inhibits Bruton's tyrosine kinase (BTK), increasing the apoptotic sensitivity of malignant cells and causing lymphocyte tissue redistribution. BTK is a promising target for treating CLL and other B-cell cancers. The Bruton tyrosine kinase is an important factor in B-cell differentiation, proliferation, migration, survival, and death. Ibrutinib is an oral, irreversible covalent inhibitor of this enzyme. It has demonstrated efficacy against some B-cell cancers. With the advent of ibrutinib, the approach to treating cancers has changed from cytotoxic chemotherapies to a more focused one. Ibrutinib, the first-in-class inhibitor of Bruton tyrosine kinase, and idelalisib, the first-in-class inhibitor of phosphatidylinositol 3-kinase delta, are now available to treat a variety of indolent B-cell malignancies. For this difficult-to-treat subpopulation of CLL patients with a del(17p)/TP53 mutation, this small-molecule inhibitor has shown promise. Because of its immunomodulatory qualities, it's a great option to combine with other immunotherapeutic drugs like Venetoclax. The medication has disadvantages. Our excitement for this adaptable medication is tempered by the requirement for continuous treatment and the existence of side effects such infection, hemorrhage, hypertension, and arrhythmia

Cite this article:
Mr. Tanish V. Jain*, Mr. Kunal M. Jain, Dr.Rahul B. Lovhare, Dr. S.P. Pawar. Ibrutinib: The BTK Inhibitor Used for Hematologic Maligancies. IJRPAS, April 2025; 4 (4): 79-89.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4408


Karunakaran P. Department of Medical Oncology, Cancer Institute (WIA), Chennai, Tamil Nadu, India.

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