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Author(s): Ankitha .V11, Narendra Reddy. A12, Yalmaji .21Madhu Harika. B1*3

Email(s): 1madhu.bonam12@gmail.com

Address:

    1. Vikas institute of pharmaceutical sciences, Rajahmundry 2. C.R. Reddy college of pharmacy, Eluru, India

Published In:   Volume - 4,      Issue - 2,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4206  

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ABSTRACT:
Hyptis suaveolens, commonly known as bush mint or pignut, is a fast-growing aromatic plant widely distributed across tropical and subtropical regions. It has been extensively studied for its rich phytochemical composition and diverse pharmacological activities. This review provides a comprehensive analysis of the phytochemical constituents, including flavonoids, terpenoids, alkaloids, and essential oils, that contribute to its wide spectrum of biological activities. The pharmacological properties of H. suaveolens, such as antimicrobial, antioxidant, anti-inflammatory, anticancer, and neuroprotective effects, are critically examined with insights into underlying mechanisms. Additionally, the therapeutic potential of this plant in traditional and modern medicine is discussed, highlighting its possible applications in drug development. Despite its promising bioactivities, challenges such as toxicity concerns, standardization of extracts, and clinical validation need to be addressed. This review aims to provide a consolidated understanding of H. suaveolens, emphasizing its significance in pharmacognosy and future therapeutic applications.

Cite this article:
Ankitha .V, Narendra Reddy. A, Yalmaji .V, Madhu Harika. B. Hyptis sauveolens: A Comprehensive Review of Its Phytochemistry, Pharmacology, and Therapeutic Potential. IJRPAS, Feb 2025; 4 (2): 64-73.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4206


1.    The Wealth of India (Raw Materials), Vol. V, CSIR, New Delhi, 1964:159.

2.    Peerzada N. Chemical composition of the Essential oil of Hyptis suaveolens. Molecules. 1997; 2: 165-168.

3.    Palmer E.  Chia.  Zoe:  A Biological Journal, 1891; 2 (2): 140-142.

4.    Gentry HS, Mittleman M, McCrohan PR.Introduction of chia and gumtragacanth inthe U.S.  In:  Janick J, Simon JE editors. Advances in new crops.  Portland:  Timber Press, 1990. 252-56.

5.    Edeoga HO, Omosun G, Uche LC (2006) Chemical composition of Hyptis suaveolens and Ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol 5(10):892–895, CAS, Google Scholar

6.    Cragg M, Newman DJ (2013) Natural products: a continuing source of novel drug leads. Biochem Biophys Acta 1830:3670–3695, Article, CAS, PubMed, Google Scholar

7.    Edeoga HO, Omosun G, Uche LC (2006) Chemical composition of Hyptissuaveolens and Ocimum gratissimum hybrids from Nigeria. Afr J Biotechnol5(10):892–895

8.    Manchand PS, White JD, Fayos Jand Clardy J. Chemical constituents of tropical plants.  V. Structures of suaveolic acid and suaveolol. The Journal of Organic Chemistry,1974; 39(15): 2306-8.

9.    Misra TN, Singh RS and Upadhyay TriTerpenoids from Hyptis-Suaveolens Roots. Phytochemistry, 1983; 22 (2): 603-5. 

10. Raja RKV, Rao LJM and Prakash RNS.  An Ar-ring contracted triterpenoid from Hyptis suaveolens. Phytochemistry. 1990; 29: 1326-8. 

11. Ziegler HL, Jensen TH, Christensen J, Staerk D and Hagerstr H.Possible Artefacts in the in vitro Determination of Antimalarial Activity of Natural Products that Incorporate into Lipid Bilayer:  Apparent Antiplasmodial Activity ofDehydroabietinol, a Constituent of Hyptis suaveolens. Planta Med, 2002; 68(6): 547-9.

12. Iwu Mm, EzeugwuCo, Okunji Co, Sanson DRand Tempesta MS.Antimicrobial Activity andTerpenoids of the Essential Oil of Hyptis Suaveolens.  Pharmaceutical Biology, 1990; 28(1):73-76.

13. Pankaj Oudhia. Traditional Medicinal Knowledge about Herbs used in Treatment of Cancer in Chhattisgarh, India. XXII. Interactions with the Traditional Healers of Saraipali Region.www.botanical.com/site/column_poudhia/.../journal.cgi.

14. Adeolu OE, Adeleke AK, Giwa AAO. Chemical composition of essential oils of Hyptis suaveolens (L.) Poit leaves from Nigeria, Flavour and Fragrance Journal 2005; 20: 528-530.

15. Tchoumbougnang F, Zollo PHA, Boyom FF, Nyegue MA, Bessiere JM, Menut C. Comparative study of the essential oils of four Hyptis species from Cameroon: H. lanceolata Poit., H. pectinata (L.) Poit., H. spicigera Lam. and H. suaveolens Poit, Flavour-and-Fragrance-Journal. 2005; 20(3): 340-343.

16. Joseph J, Jeeva S. GC-MS and FT-IR analysis of a coastal medicinal plant-Hyptis suaveolens (L.) Poit. J Coast Life Med. 2016;4(5):380–385.

17. Prasanna S, Koppula SB. Antimicrobial and preliminary phytochemical analysis of solvent extracts of Hyptis suaveolens from banks of river Krishna. Int J Pharma Sci. 2012;1(1):11–15.

18. Dhamale P, Manikpuriya S, Sanap G, Pardhe A. The phytochemical and pharmacological screening of Hyptis Suaveolens. WJPPS. 2023;14(1):239–246.Google Scholar

19. Islam A, Ohno O, Suenaga K, Kato-Noguchi H. Suaveolic acid: a potent phytotoxic substance of Hyptis suaveolens. Sci World J. 2014;2014(1):425942.Google Scholar

20. Agarwal K, Varma R (2013) Antioxidant activity and phytochemical analysis of Hyptis suaveolens (L)Poit. J Adv Pharm Educ Res 3(4):541–549

21. Gulcin I, Elmastas M, Hassan A-EY (2007) Determination of antioxidant and radical scavenging activity of basil (Ocimum basilicum L. family Lamiacae) assayed by different methodologies. Phytother Res. 21(4):354–361

22. Economou KD, Oreopoulou V, Thomopoulos (1991) Antioxidant activity of some plant extracts of the family Labiatae. J Am Oil Chemist Soc 68:109–113, Article, Google Scholar

23. Maksimovic Z, Stojanovic D, Sostaric I, Dajic Z, Ristic M (2008) Composition and radical- scavenging activity of Thymus glabrescensWilld. (Lamiacae) essential oil. J Sci Food Agric 88(11). https://doi.org/10.1002/jsfa.3311

24. Ghaffari H, Ghassam JB, Nayaka CS, Prakash SHK (2014) Antioxidant and neuroprotective activities of Hyptis suaveolens Poit, against oxidative stress-induced neurotoxicity. Cell Mol Neurobiol 34:323–331, Article, PubMed, PubMed Central, Google Scholar

25. Rice Evans CA, Miller NJ, Bolwell PG, Broamley PM, Pridham JB (1995) The relative antioxidant activities of plant derived polyphenolic flavonoids. Free Radic Res 22(4):375–383, Article, CAS, PubMed, Google Scholar

26. Cook NC, Samman S (1996) Review: flavonoid chemistry,metabolism, cardioprotective effect and dietry sources. J Nutr Biochem 7(4):66–76, Article, CAS, Google Scholar

27. Hussain TR, Tan B, Yin Y, Blachier F, Tossou MCB, Raju (2016) Oxidative stress and inflammations: what polyphenols can Do for us? Oxid Med Cell Longev. 10.1155/2016/7432797 [DOI] [PMC free article] [PubMed]

28. Oteiza PI, Erlejman AG, Verstraeten KCL, Fraga CG. Flavonoids membrane interactions: a protective role of flavonoids at the membrane surface. Clin Dev Immunol. 2005;12(1):19–25. doi: 10.1080/10446670410001722168. [DOI] [PMC free article] [PubMed] [Google Scholar]

29. Pham HNT, Sakaff JA, Vuong Q, Von Bowyer MC, Scarlett CJ (2018) Screening of phytochemical content, antioxidants, antimicrobial and cytotoxic activities of Catharanthus roseus (L.) G. Don. Stem extract and its fraction. Biocatal Agric Biotechnol 16:405–411.

30. Evans WC (2009) Flavone and related flavonoid glycosides, Trease and Evans Pharmacognosy (16th Eds). Saunders Elsevier Publication, International Edition (Edinburg, London, New York, Philadelphia, St. Louis, Sydney). Pp. 252–259

31. Jesus JA, Lago JH, Laurenti MD, Yamamoto ES, Passero LF (2015). Antimicrobial activity of oleanic and ursolic acid: An update, evidence based complementary and alternative medicine, https://doi.org/10.1155/2015/620472

32. Bachheti RK, Rai I (2015) Chemical composition and antimicrobial activity of Hyptis suaveolens Poit. Seed oil from Uttarakhand state, India. Orient Pharm Exp Med 15:141–146, Article, Google Scholar

33. Nantitanon W, Chowwanapoonpohn S, Okongi S (2007) Antioxidant and antimicrobial activities of Hyptis suaveolens essential oil. Scientia Pharmaceutica (Scipharm) 75:35–46, Article, CAS, Google Scholar

34. Asekun OT, Ekundayo O, Adeniyi BA. Antimicrobial activity of the essential oil ofHyptis suaveolens leaves.  Fitoterapia, 1999; 70(4): 440-2. 

35.  Mandal SM, Mondal KC, Dey S and Pati BR.Antimicrobial activity of the leaf extracts ofHyptis suaveolens (L.)  Poit.  Indian J Pharm Sci., 2007; 69: 568-9

36. Iwu Mm, Ezeugwu Co, Okunji Co, Sanson DRand Tempesta MS.Antimicrobial Activity andTerpenoids of the Essential Oil of Hyptis Suaveolens.  Pharmaceutical Biology, 1990; 28(1):73-76.

37. Malele RS, Mutayabarwa CK, Mwangi JW and Thoithi GN. Essential Oil of Hyptis suaveolens (L.)  Poit.  from Tanzania:  Composition andAntifungal Activity.  Journal of Essential Oil Research, 2003; 15(6): 438–40.

38. DanmalamUH, Abdullahi LM, Agunu A andMusa KY.Acute toxicity studies andHypoglycaemic activity of the methanol extract of the leaves of Hyptis suaveolens Poit. (Lamiaceae).  Nigerian Journal of Pharmaceutical Sciences, 2009; 8(2): 87-92

39. Mishra BS, Verma A, Mukerjee A, Vijay Kumar M (2011) Anti- hyperglycemic activity of leaves extract of Hyptis suaveolens L Poit in Streptozotocin induced diabetic rats. Asian Pac J Trop Med. 4(9):689-693. https://doi.org/10.1016/s1995-7645(11)60175-2

40. Castro AJG, Silva FRMB (2015) The mechanism of action of Ursolic acid as insulin secretagogue and insuliniometric is mediated by cross talk between calcium and kinase to regulate glucose balance. Biochemica et Biophysica Acta (BBA) 1850(1):51–61. https://doi.org/10.1016/j.bbagen.2014.10.001 Article, CAS, Google Scholar

41. Jang SM, Yee ST, Choi J, Choi MS, Do GM, Jecon SM, Yeo J, Kim MJ, Ki S, Lee MK (2009) Ursolic acid enhances the cellular immune system and pancreatic beta cell function in streptozotcitin induced diabetic mice fed high fat diet. Int J Immunopharmacol 9:113–119

42.  Das PK, Sahoo S, Sethi R, Nayak PS, Nayak S, Joshi A. Phytochemical and pharmacological investigation of the protective effect of plant Hyptis suaveolens against duodenal ulceration. Journal of Global Pharma Technology, 2009; 1(1): 82-87

43. Dawet A, Anyanwu Dede MP, Uzolgwe (2012) In-vivo antimalarial activity of the ethanolic leaf extracts of Hyptis suaveolens Poit. On plasmodium berghei in mice. Int J Biol Chem Sci 6(1). https://doi.org/10.4314/ijbcs.v6i1.11

44. Chukwujekwu JC, Smith P, Coombes PH, Mulholland DA, Staden JV (2005) Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens J. Ethnopharmacol 102(2):295–297.

45. Odugbemi TO, Akinsulire OR and Aibinu IE, Fabeku PO. Afr. J. Trad. CAM, 2007; 4(2): 191-198

46. Chukwujekwu JC, Smith P, Coombes PH, Mulholland DA and Staden J Van. Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens.  Journal of Ethnopharmacology, 2005; 102(2): 295-7.

47. Shenoy C, Patil MB, Kumar R (2009) Wound healing activity of Hyptis suaveolens (L) Poit (Lamiaceae). Int J PharmTech Res 1:737–744, Google Scholar

48. Shenoy C, Patil MB, Kumar R. Wound healing activity of Hyptis suaveolens L.) Poit. International Journal of PharmTech Research. 2009; 1(3): 737-744.

49. Shirwaikar A, Shenoy R, Udupa AL, Udupa SL and Shetty S. Wound healing effect of ethanol extract of leaves of Hyptis suaveolens with suppoertive Role of antioxidant. Indian J Exp Biol.2003; 41(3): 238-41.

50. Grassi P, Urias TS, Reyes U, Tubaro A, Hofer O, Karin Z-E (2006) Anti-inflammatory activity of two Diterpenes of Hyptis suaveolens from EI Salvador, pp 165–170, Google Scholar

51. Bariecevic D, Sosa S, Loggia RD, Tubaro A, Simonovoska B, Kransa A, Zupancic A (2001) Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of Ursolic acid. J Ethnopharmacol 75(2-3):125–132. https://doi.org/10.1016/S0378-8741(00)00396-2,Article,Google Scholar

52. Shenoy R, Shirwaekar A (2002) Anti-inflammatory and free radical scavenging studies of Hyptis suaveolens (Labiateae). Indian Drugs 39(11):574–577, Google Scholar

53.Uritu C, Mihai TC (2018) Medicinal plants of the family Lamiacae in pain therapy; a review. Pain Res Manag 1:1–44.

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