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Author(s): Patlolla Pravalika*1, Mamindla Ravali2, Endulal Akash3, Mudavath Sindhu4, Tadikonda Rama Rao5

Email(s): 1pravalika.jntu@gmail.com

Address:

    CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana,India-501401

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4604  

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ABSTRACT:
A novel anti-ischemic medication for the treatment of angina is ranolazine, a derivative of piperazine. The function of ranolazine is to suppress late INa, hence avoiding cell sodium overload. Ranolazine thereby inhibits reverse mode sodium-calcium exchange, which in turn inhibits the diastolic buildup of calcium. This may lead to an improvement in diastolic tone and coronary blood flow. Myocardial ischaemia is treated with ranolazine, which affects sodium-dependent calcium channels. This review article represents the various analytical methods which has been reported for estimation of Ranolazine in bulk drug and its dosage forms. The spectrophotometric techniques like UV, Visible and fluorescence spectroscopy; Chromatographic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.

Cite this article:
Patlolla Pravalika, Mamindla Ravali, Endulal Akash, Mudavath Sindhu, Tadikonda Rama Rao. Analytical Methods for the Estimation of Ranolazine in Bulk and Dosage Forms: A Comprehensive Review. IJRPAS, June 2025; 4 (6): 36-49.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4604


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