Abstract View

Author(s): Manbir Kaur*1, Ravika Nanda2, Rupinder Kaur3, Pooja Kohar4

Email(s): 1manbirmanu@yahoo.com

Address:

    Department of Pharmacy, Global Group of Institutes, Amritsar

Published In:   Volume - 4,      Issue - 2,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4112  

 View HTML        View PDF

Please allow Pop-Up for this website to view PDF file.

ABSTRACT:
This study evaluates the anthelmintic activity of various extracts of Careya arborea, a medicinal plant traditionally used in ethnomedicine. Soxhlet extraction method, was employed to isolate bioactive compounds. The anthelmintic efficacy was assessed against earthworms using standard assays that measured paralysis and mortality rates at various concentrations (25 and 50 mg/mL). The results indicated a significant dose-dependent effect, with acetone extracts demonstrating the highest activity, effectively inducing paralysis and mortality in the test organisms. These findings support the traditional use of Careya arborea and suggest its potential as a natural anthelmintic agent, warranting further investigation into its active constituents and mechanisms of action.

Cite this article:
Manbir Kaur, Ravika Nanda, Rupinder Kaur, Pooja Kohar. Evaluation of Anthelmintic Activity of Different Extracts of Careya arborea.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4112


1.      Stojanoski, N. Development of health culture in Veles and its region from the past to the end of the 20th century. Veles: Society of science and art, 1999; 13:34-34.

2.      Kelly, K. The history of medicine. New York: Facts On File, 2009.

3.      Savioli, L. and Albonico, M. Focus: Soil-transmitted helminthiasis. Nature Reviews Microbiology, 2004; 2(8): 618-619.

4.      Cappello, M. Global health impact of soil-transmitted nematodes. The Pediatric infectious disease journal, 2004; 23(7): 663-664.

5.      De Silva, N.R., Brooker, S., Hotez, P.J., Montresor, A., Engels, D. and Savioli, L. Soil-transmitted helminth infections: updating the global picture. Trends in parasitology, 2003; 19(12): 547-551.

6.      Stephenson, L.S., Latham, M.C. and Ottesen, E.A. Malnutrition and parasitic helminth infections. Parasitology, 2000; 121(S1): 23-38.

7.      Chway, H.M., Montresor, A., Tielsch, J.M., Jape, J.K., Albonico, M., Savioli, L. and Stoltzfus, R.J. Low dose daily iron supplementation improves iron status and appetite but not anemia, whereas quarterly anthelminthic treatment improves growth, appetite and anemia in Zanzibari preschool children. The Journal of nutrition, 2004; 134(2): 348-356.

8.      Drake, L.J., Jukes, M.C.H., Sternberg, R.J. and Bundy, D.A.P., October. Geohelminth infections (ascariasis, trichuriasis, and hookworm): cognitive and developmental impacts. In Seminars in Pediatric Infectious Diseases, 2000; 11(4): 245-251.

9.      Guyatt, H. Do intestinal nematodes affect productivity in adulthood?. Parasitology Today, 2000; 16(4): 153-158.

10.  Hotez, P.J., Brindley, P.J., Bethony, J.M., King, C.H., Pearce, E.J. and Jacobson, J., 2008. Helminth infections: the great neglected tropical diseases. The Journal of clinical investigation118(4): 1311-1321.

11.  King, C.H. Lifting the burden of schistosomiasis—defining elements of infection-associated disease and the benefits of antiparasite treatment. The Journal of infectious diseases, 2007; 196(5): 653-655.

12.  Budke, C.M., Jiamin, Q.I.U., Qian, W. and Torgerson, P.R. Economic effects of echinococcosis in a disease-endemic region of the Tibetan Plateau. American Journal of Tropical Medicine and Hygiene, 2005; 73(1): 2-10.

13.  Hotez, P.J., Molyneux, D.H., Fenwick, A., Kumaresan, J., Sachs, S.E., Sachs, J.D. and Savioli, L. Control of neglected tropical diseases. New England journal of medicine, 2007; 357(10): 1018-1027.

14.  Hotez, P.J., Brindley, P.J., Bethony, J.M., King, C.H., Pearce, E.J. and Jacobson, J. Helminth infections: the great neglected tropical diseases. The Journal of clinical investigation, 2008; 118(4): 1311-1321.

15.  Breedlove, B. and Bradbury, R. Tapeworm Enigma. Emerging Infectious Diseases, 2022; 28(6): 1306.

16.  Jourdan, P.M., Lamberton, P.H., Fenwick, A. and Addiss, D.G. Soil-transmitted helminth infections. The lancet, 2018; 391(10117): 252-265.

17.  Novianty, S., Dimyati, Y., Pasaribu, S. and Pasaribu, A.P. Risk factors for soil-transmitted helminthiasis in preschool children living in farmland, North Sumatera, Indonesia. Journal of tropical medicine, 2018.

18.  Mascarini-Serra, L. Prevention of soil-transmitted helminth infection. Journal of global infectious diseases, 2011; 3(2): 175-182.

19.  Sharma, S., Hashmi, M.F. and Alhajjaj, M.S. Stat Pearls Publishing. Treasure Island (FL): 2021 Aug, 4.

20.  Jourdan, P.M., Lamberton, P.H., Fenwick, A. and Addiss, D.G. Soil-transmitted helminth infections. The lancet, 2018; 391(10117): 252-265.

21.  Das, A.K. Hepatic and biliary ascariasis. Journal of Global Infectious Diseases, 2014; 6(2), pp.65-72.

22.  Ambardar, N. and Aeri, V. A better understanding of traditional uses of Careya arborea Roxb.: Phytochemical and pharmacological review. CELLMED, 2013; 3(4): 281.

23.  Das, M.C. Triterpenoid sapogenols from the leaves of Careya arborea: structure of careyagenolide. Phytochemistry, 1982; 21(8): 2069-2073.

24.  Basak, A., Banerjee, S.K., Bose, L. and Basu, K. CHEMICAL EXAMINATION OF LEAVES OF CAREYA-ARBOREA. JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1976; 53(6): 639-640.

25.  Mahato, S.B. and Dutta, N.L. Sterols from Careya arboreaPhytochemistry, 1972; 11(6),: 2116-2117.

26.  Talapatra, B., Basak, A. and Talapatra, S.K. TERPENOIDS AND RELATED-COMPOUNDS. 20. CAREABORIN, A NEW TRITERPENE ESTER FROM THE LEAVES OF CAREYA-ARBOREAJournal of the Indian Chemical Society, 1981; 58(8),: 814-815.

27.  Gupta, R.K. Tannin bearing plants of India from denuded wastelands. J Econ Tax Bot, 1981; 2: 139-155.

28.  Haloi, K., Kalita, E. and Kalit, J.C. Effects of methanolic root extract of Careya arborea Roxbon ovarian histology of albino mice. Nebio, 2010; 1(1).

29.  Manbir Kaur, Rakesh Yadav. Pharmacognostic, ethno-pharmacological, phytochemical and pharmacological profile of wild guava I.E. Careyaarborearoxb. Int J Curr Pharm Res 2017;9 (3):1-7.

30.  Kumar, R.S., Sundram, R.S., Sivakumar, P., Nethaji, R., Senthil, V., Murthy, N.V. and Kanagasabi, R. CNS activity of the methanol extracts of Careya arborea in experimental animal model. Bangladesh Journal of Pharmacology, 2008; 3(1): 36-43.

31.  Senthilkumar, N., Badami, S., Cherian, M.M. and Hariharapura, R.C. Potent in vitro cytotoxic and antioxidant activity of Careya arborea bark extracts. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 2007; 21(5): 492-495.

32.  Ramesh, H.A. and Shenoy, D.B. Effect of Careya arborea extracts on wound healing activity in rats. International Journal of Analytical, Pharmaceutical and Biomedical Sciences, 2013; 2 (1): 36-42.

33.  Rayhana, B., Sheliya, M.A., Pillai, K.K., Aeri, V. and Sharma, M. Evaluation of anti-inflammatory effect of Careya arborea in CFA induced chronic inflammation. Int. J. Pharm. Sci. Rev. Res, 2014; 26(2): 292-298.

34.  Chothani, D.L. and Patel, N.M. Anti-allergic potential of methanolic extract of leaves and fruits of Careya arboreaJournal of Pharma Sci Tech, 2014; 4(1): 29-31.

35.  Shinde, G.S., Karadi, R.V., Khedkar, A.S., Dere, P.J., Mandavkar, Y.D. and Khalure, P.R. Screening of Careya arborea Roxb for their anticonvulsant properties in experimental animals. International Journal of Green Pharmacy (IJGP), 2013; 7(1).

36.  Kumar, K., Mruthunjaya, K., Kumar, S. and Mythreyi, R. Anti-ulcer activity of ethanol extract of the stem bark of Careya arborea Roxb. International Current Pharmaceutical Journal, 2013; 2(3): 78-82.

37.  Karunakar, N., Pillai, K.K., Husain, S.Z. and Rao, M. Investigations of anti-inflammatory activity of Jigrine. Indian journal of physiology and pharmacology, 1997; 41: 134-138.

38.  Sambath Kumar, R. Hepatoprotective and in vivo antioxidant effects of Careya arborea against carbon tetrachloride induced liver damage in rats. Int J Mol Med Adv Sci., 2005; 1: 418-424.

 

Related Images:



Recent Images



Nanotechnology in Cosmetic Formulations: Recent Advances and Safety Concerns
Analysis of Pro-Inflammatory Cytokines Response Among Typhoid Patients Co-Infection with Plasmodium falciparum In Khartoum State -Sudan
Optimizing OEL and ADE/PDE Compliance in Pharma
Formulation and Evaluation of Quercetin Nanoemulsion Gel for Rheumatoid Arthritis
Formulation and Evaluation of Herbal Oil -Roghan-e-Turb: A Traditional Unani Formulation for Analgesic Activity
Formulation and Evaluation of Anti-Pimple Herbal Serum Enriched with Tulsi, Turmeric, Aloe Vera, Neem
Formulation, Optmization and Evaluation of Curcuma longa and Piper nigrum Hydrogel
A Review on Emerging Technologies in Monitoring and Diagnosing Immune Thrombocytopenia (ITP): Current Trends and Future Directions
Phytochemical Characterisation, In Silico Androgen Receptor Inhibitory Activity, and Fertility-Enhancing Potential of Aqueous–Ethanol Root Extract of Triclisia subcordata Oliv.
Formulation of Effervescent Granules from Bangkal Tree (Nauclea orientalis) Leaf Extract: A Potential  Larvicide Against Aedes Aegypti

Tags