International Journal of Research in Pharmacy and Allied Science

ISSN: 2583-6544   |  Issues per year: Monthly  |   Indexed In: Google Scholar, CORE, ScienceOpen, Researchgate

ISSN:2583-6544

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Neuroprotective Role of Sovateltide in Ischemic Stroke: A Review of Preclinical and Clinical Evidence

Author(s): Abishek S1*1, S.Lavanya22, Balakrishnan R33

Email(s): 1abisheksaravanan3@gmail.com

Address:

    1. M.Pharm, Department of Pharmacy Practice, PSG College of Pharmacy,Coimbatore 2. Professor, Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore 3. Head and Department of Neurology, PSG Hospital, Coimbatore

Published In:   Volume - 4,      Issue - 6,     Year - 2025

DOI: https://doi.org/10.71431/IJRPAS.2025.4608  

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ABSTRACT:
There are few treatment options for ischemic stroke, which mostly focuses on reperfusion, and it continues to be a leading cause of mortality and permanent disability globally. Neuroprotective medicines are desperately needed in order to improve functional recovery and encourage brain restoration. The capacity of sovateltide, a novel selective endothelin B (ETB) receptor agonist, to promote neurogenesis, angiogenesis, and decrease neuronal death has made it a viable candidate. This review synthesizes current preclinical and clinical evidence regarding the efficacy and safety of sovateltide in ischemic stroke management. Preclinical studies in rodent models demonstrated significant reductions in infarct size, improved motor function, increased expression of neurotrophic factors, and enhanced neural stem cell proliferation. According to clinical data from Phase II and III randomized controlled trials, patients receiving sovateltide had noticeably better functional outcomes than those receiving standard care alone, as indicated by the modified Rankin Scale (mRS), National Institutes of Health Stroke Scale (NIHSS), and Barthel Index. Importantly, no major adverse effects were reported, supporting its favorable safety profile. These findings indicate that sovateltide offers neuroprotective benefits beyond current reperfusion therapies. Future large-scale trials and long-term follow-up studies are warranted to confirm its therapeutic potential and optimize its clinical use in ischemic stroke treatment.

Keywords:

Cite this article:
Abishek S, S.Lavanya, Balakrishnan R. Neuroprotective Role of Sovateltide in Ischemic Stroke: A Review of Preclinical and Clinical Evidence. IJRPAS, June 2025; 4 (6): 80-85.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4608


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