ABSTRACT:
The goal of the study was to assess the antispasmodic qualities of Curcuma Amada Roxb. (mango ginger) rhizomes. The roots, leaves, and petals of this species have also been used to treat a variety of illnesses. Food consumption, digestion, nutrient absorption, and waste elimination all take place in the gastrointestinal system. Digestion and general health may be adversely affected by a number of GI-related diseases. Common digestive problems include peptic ulcers, constipation, diarrhea, and IBS (Irritable Bowel Syndrome). Any illness affecting the gastrointestinal tract is referred to as a GIT ailment. This study aimed to investigate the antispasmodic effects of Curcuma Amada Roxb. rhizomes on the smooth muscle's voluntary motility and contractility in chicken ileum in vitro. The study evaluates the antispasmodic effects of Curcuma Amada Roxb. rhizomes on intestinal contraction using the ileum of chickens. Botanicals such as Artemisia vulgaris, Glycyrrhiza uralensis, and Zingiber officinale are used in traditional therapies for GIT disorders. This study found that the rhizome aqueous extract of Curcuma Amada Roxb. possesses antispasmodic activities in intestinal tissue, indicating that it could be used as an antidiarrheal drug.
Cite this article:
Dr. Sundhararajan R, Sanjukta Sainath Singh*, Jenifer J, Keerthana P, Kiruthika. In-Vitro Evaluation of Antispasmodic Activity of Rhizomes of Curcuma Amada Roxb. IJRPAS, March 2025; 4 (3): 57-63.DOI: https://doi.org/https://doi.org/10.71431/IJRPAS.2025.4308
1. Corazziari E: Definition and epidemiology of functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18:613–631.
2. Waugh A, Grant A. Ross & Wilson Anatomy and physiology in health and illness E-book. Elsevier Health Sciences; 2014 Jun 25.
3. Roy choudhury S, Das D, Das S, Jha NK, Pal M, Kolesarova A, Kesari KK, Kalita JC, Slama P. Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study. Molecules. 2022 Oct 18;27(20):7039.
4. Yassin NA, El-Rokh ES, El-Shenawy SM, Ibrahim BM. The study of the antispasmodic effect of ginger (Zingiber officinale) in vitro. Der Pharmacia Lettre. 2012;4(1):263-274.
5. Nagai H, Yamamoto Y, Sato Y, Akao T, Tani T. Pharmaceutical evaluation of cultivated Glycyrrhiza uralensis roots in comparison of their antispasmodic activity and glycycoumarin contents with those of licorice. Biological and Pharmaceutical Bulletin. 2006;29(12):2442-2445.
6. Khan AU, Gilani AH. Antispasmodic and bronchodilator activities of Artemisia vulgaris are mediated through dual blockade of muscarinic receptors and calcium influx. Journal of ethnopharmacology. 2009 Dec10;126(3):480-486.
7. Policegoudra RS, Aradhya SM and Singh L Mango ginger (Curcuma amada Roxb) – A promising spice for phytochemicals and biological activities. J. Biosci 2011; (36): 739–748) DOI 10.1007/s12038011-9106-1.
8. Kashyap NK, Deepak J, Bhardwaj AK, Hait M, Pal D. In-vitro Antibacterial and Antifungal Activity of Curcuma Amada Roxb. Against Human Pathogens. Trends in Sciences. 2022; 19(22): 4839. https://doi.org/10.48048/tis.2022.4839.
9. Prakash O, Anita T, Punetha H, Pant AK. Phytochemical Profiling and Antifungal Activity of Essential Oil and Rhizome Extracts of Curcuma Amada Roxb. Organic & Medicinal Chem IJ. 2017; 4(1): 555627. DOI: 10.19080/OMCIJ.2017.04.555627.
10. Ramachandran, Cheppail & Lollett, Ivonne & Escalon, Enrique & Quirin, Karl-Werner & Melnick, Steven. Anticancer Potential and Mechanism of Action of Mango Ginger (Curcuma amada Roxb.) Supercritical CO2 Extract in Human Glioblastoma Cell. J evidence-based complementary & alternative medicine. 2015; 20.10.1177/2156587214563731.
11. Arunaksharan Narayanankutty, Anju Sasidharan, Joice Tom Job, Rajakrishnan Rajagopal, Ahmed Alfarhan, Young Ock Kim, Hak- Jae Kim. Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: Comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods. Environmental Research. 2021; 202. https://doi.org/10.1016/j.envres.2021.111718
12. Lata Choudhary, Ritesh Jain, Satish Sahu. Mango Ginger – Curcuma amada – The Uncommon Spice with Uncommon Pharmacotherapeutic Potentials. Res J Pharmacy Technology. 2024; 17(3):1418-4. doi: 10.52711/0974-360X.2024.00225.
13. Syiem, Don, Monsang Warson Sharma Ramesh. Hypoglycemic and antihyperglycemic activity of Curcuma amada Roxb. In normal and alloxan-induced diabetic mice. Pharmacology online. 2010; 3: 364-372.
14. Yazici, Emrah & Sahin, Emre & Şahin, Nurhan & Tuzcu, Mehmet & Sahin, Kazim & Orhan, Cemal. Mango ginger (Curcuma amada Roxb.) may alleviate the effect of high fat diet/streptozotocin induced diabetes by activation of the GSK 3β/Fyn/Nrf2 pathway. Food Science & Nutrition. 2023: 11. 10.1002/fsn3.3539.
15. Mujumdar, Arvind & Naik, Dattatraya & Dandge, C & Puntambekar, Hemalata. Anti - inflammatory activity of Curcuma amada roxb. In albino rats. Indian J Pharmacology. 2002; 32.